Emerging roles of TRIM27 in cancer and other human diseases

Yu, Chengpeng; Rao, Dean; Wang, Tiantian; Song, Jia; Zhang, Lei; Huang, Wenjie

doi:10.3389/fcell.2022.1004429

Cited by 13 publications

(3 citation statements)

References 106 publications

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“…TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and contributes to tumorigenesis in BC. 38 , 154 …”

Section: The Roles Of Trims In Bcmentioning

confidence: 99%

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Emerging roles of tripartite motif family proteins (TRIMs) in breast cancer

Cao,

Yang,

Guo

et al. 2024

Cancer Medicine

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Breast cancer (BC) is the most common malignant tumor worldwide. Despite enormous progress made in the past decades, the underlying mechanisms of BC remain further illustrated. Recently, TRIM family proteins proved to be engaged in BC progression through regulating various aspects. Here we reviewed the structures and basic functions of TRIM family members and first classified them into three groups according to canonical polyubiquitination forms that they could mediate: K48‐ only, K63‐ only, and both K48‐ and K63‐linked ubiquitination. Afterwards, we focused on the specific biological functions and mechanisms of TRIMs in BCs, including tumorigenesis and invasiveness, drug sensitivity, tumor immune microenvironment (TIME), cell cycle, and metabolic reprogramming. We also explored the potential of TRIMs as novel biomarkers for predicting prognosis and future therapeutic targets in BC.

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“…TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and contributes to tumorigenesis in BC. 38 , 154 …”

Section: The Roles Of Trims In Bcmentioning

confidence: 99%

“…It was revealed that TRIM27 is a novel negative regulator of autophagy. TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and contributes to tumorigenesis in BC 38,154 …”

Section: The Roles Of Trims In Bcmentioning

confidence: 99%

Emerging roles of tripartite motif family proteins (TRIMs) in breast cancer

Cao,

Yang,

Guo

et al. 2024

Cancer Medicine

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“…The tripartite motif containing 27 (TRIM27), also known as Red Fluorescent Protein (RFP), belongs to the TRIM protein family characterized by the tripartite motif [17]. TRIM27 is involved in multiple cellular processes, including innate immunity, inflammation, and autophagy [18].…”

Section: Introductionmentioning

confidence: 99%

TRIM27-Induced Protective Autophagy: A Novel Therapeutic Approach for Pneumonia

Pang,

Wang,

Xie

et al. 2024

Discovery Medicine

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Background: Pneumonia is a prevalent respiratory ailment involving complex physiological and pathological mechanisms. The tripartite motif containing 27 (TRIM27) plays a crucial role in regulating inflammation mechanisms. Therefore, the purpose of this study is to further explore the therapeutic potential of TRIM27 in pneumonia, based on its regulatory mechanisms in inflammation and autophagy. Methods: This study established a mouse pneumonia animal model through lipopolysaccharide (LPS) administration, designating it as the LPS model group. Subsequently, adenovirus-mediated TRIM27 overexpression was implemented in the animals of the LPS model group, creating the TRIM27 treatment group. After a 7-day treatment period, lung tissues from the mice were collected. Various techniques, including immunohistochemistry, quantitative reverse transcription PCR (RT-qPCR), western blot, enzyme-linked immunosorbent assay (ELISA), and electron microscopy were utilized to analyze the impact of TRIM27 overexpression on inflammatory factors, oxidative stress, autophagy, and inflammatory processes in pulmonary tissues. Finally, an in vitro LPS cell model was established, and the effects of TRIM27 overexpression and autophagy inhibition on inflammatory cytokines and autophagosomes in LPS-induced inflammatory cells were examined through RT-qPCR and immunofluorescence techniques. Results: The research findings demonstrate a significant reduction in the elevated levels of interleukin-6 (IL-6), IL-1β, and Tumor necrosis factor-alpha (TNF-α) induced by LPS with TRIM27 overexpression (p < 0.01). Conversely, the autophagy inhibitor 3-Methyladenine (3-MA) diminished the effects induced by TRIM27 overexpression. Moreover, TRIM27 overexpression enhanced the expression of Microtubule-associated protein 1A/1B light chain 3 (LC3) II/I and Beclin-1 proteins in mice subjected to LPS stimulation (p < 0.01), while reducing the expression of the p62 protein (p < 0.01). The addition of 3-MA, however, decreased Beclin-1 expression and inhibited autophagy (p < 0.01). Additionally, TRIM27 overexpression decreased the expression of NODlike receptor thermal protein domain associated protein 3 (NLRP3), cleaved caspase-1, IL-1β, and Gasdermin D N-terminal fragment (GSDMD-N) proteins in LPS-stimulated mice (p < 0.05). TRIM27 overexpression also decreased the levels of malondialdehyde (MDA), Activating Transcription Factor 6 (ATF6), and C/EBP-homologous protein (CHOP), while increasing the levels of superoxide dismutase (SOD) and glutathione (GSH) in mice exposed to LPS (p < 0.01). Conclusion: The induction of TRIM27 overexpression emerges as a potential and effective pneumonia treatment. The underlying mechanism may involve inducing protective autophagy, thereby reducing oxidative stress and cell pyroptosis.

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Multifaceted role of TRIM28 in health and disease

Maghsoudloo,

Mokhtari,

Jamali

et al. 2024

MedComm

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The TRIM (tripartite motif) family, with TRIM28 as a key member, plays a vital role in regulating health and disease. TRIM28 contains various functional domains essential for transcriptional regulation, primarily through its interaction with KRAB‐ZNF proteins, which influence chromatin remodeling and gene expression. Despite extensive research, the precise mechanisms by which TRIM28 impacts health and disease remain elusive. This review delves into TRIM28’s multifaceted roles in maintaining health, contributing to a variety of diseases, and influencing cancer progression. In cancers, TRIM28 exhibits a dual nature, functioning as both a tumor promoter and suppressor depending on the cellular context and cancer type. The review also explores its critical involvement in processes such as DNA repair, cell cycle regulation, epithelial‐to‐mesenchymal transition, and the maintenance of stem cell properties. By uncovering TRIM28’s complex roles across different cancers and other diseases, this review underscores its potential as a therapeutic target. The significance of TRIM28 as a versatile regulator opens the door to innovative therapeutic strategies, particularly in cancer treatment and the management of other diseases. Ongoing research into TRIM28 may yield key insights into disease progression and novel treatment options.

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Emerging roles of TRIM27 in cancer and other human diseases

Cited by 13 publications

References 106 publications

Emerging roles of tripartite motif family proteins (TRIMs) in breast cancer

Emerging roles of tripartite motif family proteins (TRIMs) in breast cancer

TRIM27-Induced Protective Autophagy: A Novel Therapeutic Approach for Pneumonia

Multifaceted role of TRIM28 in health and disease

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