2008
DOI: 10.1021/ar700120t
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Emerging Rules for Subunit-Based, Multiantigenic, Multistage Chemically Synthesized Vaccines

Abstract: S eventeen million people die of transmittable diseases and 2/3 of the world's population suffer them annually. Malaria, tuberculosis, AIDS, hepatitis, and reemerging and new diseases are a great threat to humankind. A logical and rational approach for vaccine development is thus desperately needed.Protein chemistry provides the best tools for tackling these problems. The tremendous complexity of microbes, the different pathways they use for invading host cells, and the immune responses they induce can only be… Show more

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Cited by 110 publications
(154 citation statements)
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References 66 publications
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“…Three different malaria vaccine strategies can be distinguished: infection-blocking vaccines targeting preerythrocytic stages, anti-morbidity vaccines targeting the erythrocytic stages, and transmission-blocking vaccines targeting the sexual stages. It is assumed that a highly effective malaria vaccine needs to target multiple stages of the parasite life cycle (2,3).…”
mentioning
confidence: 99%
“…Three different malaria vaccine strategies can be distinguished: infection-blocking vaccines targeting preerythrocytic stages, anti-morbidity vaccines targeting the erythrocytic stages, and transmission-blocking vaccines targeting the sexual stages. It is assumed that a highly effective malaria vaccine needs to target multiple stages of the parasite life cycle (2,3).…”
mentioning
confidence: 99%
“…experimental model which recognized recombinant protein by ELISA and WB and native protein in sporozoites using immunofluorescence. These results stress the importance of complete structural and immunologic analysis for all P. falciparum HABPs for developing multi-epitope, multistage, minimal subunit-based, chemically synthesized vaccines to ensure obtaining complete protection against malaria Patarroyo and Patarroyo 2008). Unfortunately, it was only discovered that native peptide 34458 had genetic polymorphism when polymorphism studies had been completed (as described above), thereby allowing this HABP to be classified as variable according to our strict conservation definition standards and also rule out the possibility of using 38140 modified analog as a component of a minimal subunit-based, synthetic antimalarial vaccine.…”
Section: Discussionmentioning
confidence: 73%
“…to produce a protective immune response against P. falciparum challenge in the Aotus model (Cifuentes et al 2009;Patarroyo et al 2008a;Patarroyo and Patarroyo 2008). Complete CelTOS and TRSP sequences have been finely mapped using HeLa and (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…Similar results were obtained when other modifications were made, such as changing critical residues in other analogous peptides synthesised. On the contrary, immunogenicity and protection were induced in Aotus monkeys inoculated with modified HABP 23426 where changes were made to residues T7C, L14H and T16V (Table 1), categorically confirming that critical binding residues or their neighbours have to be changed for others having similar mass and volume but apposite polarity (Cifuentes et al 2008;Patarroyo et al 2008Patarroyo et al , 2011.…”
Section: Resultsmentioning
confidence: 93%