Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7

Lanfray, Damien; Richard, Denis

doi:10.3389/fnins.2017.00328

Cited by 22 publications

(11 citation statements)

References 100 publications

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“…Previous work by Buniello and colleagues used the Genome Wide Association Studies catalogue for phenotypic risk association [ 38 ] and found that five DNA variants upstream of ACBD3 (three intergenic variants and two regulatory region variants) were associated with core binding factor acute myeloid leukaemia risk [ 39 ]. There was one other risk variant, but this was not linked to cancer but rather behaviour which is not unexpected given that several other ACBD family proteins are known to influence behaviour in animals [ 40 , 41 , 42 ]. The Genehancer database was also searched, corroborating that the same five ACBD3 variants were associated with core binding factor acute myeloid leukaemia risk; additionally, ACBD3 regulatory region variants were found that enhanced the red blood cell distribution width (a measure of red blood cell volume variation), and variants that are associated with plateletcrit (the percentage of blood volume occupied by platelets) [ 43 ].…”

Section: Resultsmentioning

confidence: 99%

ACBD3 Bioinformatic Analysis and Protein Expression in Breast Cancer Cells

Houghton-Gisby

Kerslake

Karteris

et al. 2022

IJMS

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ACBD3 overexpression has previously been found to correlate with worse prognosis for breast cancer patients and, as an incredibly diverse protein in both function and cellular localisation, ACBD3 may have a larger role in breast cancer than previously thought. This study further investigated ACBD3′s role in breast cancer. Bioinformatic databases were queried to characterise ACBD3 expression and mutation in breast cancer and to investigate how overexpression affects breast cancer patient outcomes. Immunohistochemistry was carried out to examine ACBD3 location within cells and tissue structures. ACBD3 was more highly expressed in breast cancer than in any other cancer or matched normal tissue, and expression over the median level resulted in reduced relapse-free, overall, and distant metastasis-free survival for breast cancer patients as a whole, with some differences observed between subtypes. IHC analysis found that ACBD3 levels varied based on hormone receptor status, indicating that ACBD3 could be a candidate biomarker for poor patient prognosis in breast cancer and may possibly be a biomarker for ER signal reprogramming of precancerous breast tissue.

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Section: Resultsmentioning

confidence: 99%

ACBD3 Bioinformatic Analysis and Protein Expression in Breast Cancer Cells

Houghton-Gisby

Kerslake

Karteris

et al. 2022

IJMS

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“…We found that oral administration of PNE activated hypothalamic nuclei, both the ARC and PVN, but not the VMH. In the melanocortin system, two types of ARC neurons—the POMC and NPY/AgRP—project to MC4R-expressing PVN neurons and regulate PVN neuronal activity by releasing α-MSH and γ-aminobutyric acid (GABA), respectively [ 32 , 34 , 35 ]. Moreover, several studies have shown that modulation of POMC neuronal activity is closely related to the MC3 and MC4Rs, although POMC neurons innervate MC4R-expressing neurons in the PVN [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice

Kim

Yang

Byeon

et al. 2021

Plants

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Background: Obesity due to an excessive intake of nutrient disturbs the hypothalamus-mediated energy metabolism subsequently develops metabolic disorders. In this study, we investigated the effect of pine needle extract (PNE) on the hypothalamic proopiomelanocortin (POMC) neurons involved in the regulation of energy balance via melanocortin system and fat tissue metabolism. Methods: We performed electrophysiological and immunohistochemical analyses to determine the effect of PNE on POMC neurons. Mice were fed a normal or high-fat diet for 12 weeks, then received PNE for the last 2 weeks to measure the following physiological indices: Body weight, food intake, fat/lean mass, glucose metabolism, and plasma leptin levels. In addition, changes of thermogenic, lipolytic, and lipogenetic markers were evaluated in brown adipose tissue (BAT) and white adipose tissue (WAT) by western blotting, respectively. Results: PNE increased hypothalamic POMC neuronal activity, and the effect was abolished by blockade of melanocortin 3/4 receptors (MC3/4Rs). PNE decreased body weight, fat mass, plasma leptin levels, and improved glucose metabolism after high-fat-induced obesity. However, PNE did not change the expression of thermogenic markers of the BAT in HFD fed groups, but decreased only the lipogenetic markers of WAT. This study suggests that PNE has a potent anti-obesity effect, inhibiting lipogenesis in WAT, even though HFD-induced leptin resistance-mediated disruption of POMC neuronal activity.

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“…This results in the proteolytic conversion of POMC and the release of α-MSH, which activates MC4R, promoting satiety, reduced food intake and increased energy expenditure. Leptin also binds to AgRP neurons, resulting in the suppression of AgRP release, which is a potent antagonist for MC4R and increases food intake, energy conservation and weight [ 241 , 242 ]. An incretin hormone GLP1 (glucagon-like peptide-1) that stimulates insulin secretion, and PYY (peptide YY), both secreted from the gastrointestinal tract, are also anorexigenic and delay gastric emptying and promote satiety [ 243 ].…”

Section: Mechanisms Of Chrononutrition In Energy Homeostasis and Obesitymentioning

confidence: 99%

Chrononutrition—When We Eat Is of the Essence in Tackling Obesity

Ahluwalia

2022

Nutrients

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Obesity is a chronic and relapsing public health problem with an extensive list of associated comorbidities. The worldwide prevalence of obesity has nearly tripled over the last five decades and continues to pose a serious threat to wider society and the wellbeing of future generations. The pathogenesis of obesity is complex but diet plays a key role in the onset and progression of the disease. The human diet has changed drastically across the globe, with an estimate that approximately 72% of the calories consumed today come from foods that were not part of our ancestral diets and are not compatible with our metabolism. Additionally, multiple nutrient-independent factors, e.g., cost, accessibility, behaviours, culture, education, work commitments, knowledge and societal set-up, influence our food choices and eating patterns. Much research has been focused on ‘what to eat’ or ‘how much to eat’ to reduce the obesity burden, but increasingly evidence indicates that ‘when to eat’ is fundamental to human metabolism. Aligning feeding patterns to the 24-h circadian clock that regulates a wide range of physiological and behavioural processes has multiple health-promoting effects with anti-obesity being a major part. This article explores the current understanding of the interactions between the body clocks, bioactive dietary components and the less appreciated role of meal timings in energy homeostasis and obesity.

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Emerging Signaling Pathway in Arcuate Feeding-Related Neurons: Role of the Acbd7

Cited by 22 publications

References 100 publications

ACBD3 Bioinformatic Analysis and Protein Expression in Breast Cancer Cells

ACBD3 Bioinformatic Analysis and Protein Expression in Breast Cancer Cells

Anti-Obesity Effect of Pine Needle Extract on High-Fat Diet-Induced Obese Mice

Chrononutrition—When We Eat Is of the Essence in Tackling Obesity

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