Emerging Symptomatic Treatment of Chronic Traumatic Encephalopathy (CTE): a narrative review

Rossi, C. A.; Campese, Nicole; Colosimo, Carlo

doi:10.1080/14656566.2023.2224501

Cited by 1 publication

(2 citation statements)

References 109 publications

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“…Recommendations included exercise, active rehabilitation, diet, cognitive rehabilitation, mood/behavioural therapy, occupational therapy, vestibular and motor therapy, and pharmacological therapy. This expert opinion has been reiterated by Fusco et al [ 7 ] and Rossi et al [ 8 ] in expert opinions or narrative reviews. Themes including cognitive and motor rehabilitation therapy, mindfulness, mood/behavioural therapy, occupational therapy, diet, exercise, and active rehabilitation were suggested to help manage neuropsychiatric symptoms of CTE [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 83%

“…This expert opinion has been reiterated by Fusco et al [ 7 ] and Rossi et al [ 8 ] in expert opinions or narrative reviews. Themes including cognitive and motor rehabilitation therapy, mindfulness, mood/behavioural therapy, occupational therapy, diet, exercise, and active rehabilitation were suggested to help manage neuropsychiatric symptoms of CTE [ 7 , 8 ]. Finally, an umbrella review [ 9 ] has reported the effect that active rehabilitation has on other tauopathies with symptoms associated with CTE.…”

Section: Introductionmentioning

confidence: 83%

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The effects of person-centred active rehabilitation on symptoms of suspected Chronic Traumatic Encephalopathy: A mixed-methods single case design

Hearn,

Selfe,

Cordero

et al. 2024

PLoS ONE

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Objective The objective was to investigate the effectiveness of a person-centred active rehabilitation programme on symptoms associated with suspected Chronic Traumatic Encephalopathy (CTE). This was accomplished by (1) assessing the effect that a person-centred active rehabilitation programme had on participant symptoms, and (2) exploring how temporal contextual factors affected the participants’ experience with, and perceived effectiveness of, the active rehabilitation programme. Methods A twelve-month mixed-methods single case experimental research design was used with six cases (participants). Individual cases were involved in a 51-week study period including an initial interview and three-week baseline phase. Cases were then randomly allocated to one of two n-of-1 study designs (i.e., A-B, B-A, B-A, A-B or B-A, A-B, A-B, B-A) where A and B represent a non-intervention and intervention phase, respectively. Interviews were conducted regularly throughout the study whilst outcome measures were assessed at each follow-up. Analysis of the data included visual, statistical, and qualitative analysis. Results Visual and statistical analysis of cognitive and executive function, and mindful attention, demonstrated trivial-to-large effects with the summary reflecting positive or unclear results. A mixed picture was observed for mood and behaviour with effects considered trivial-to-large, and the summary demonstrating positive, unclear and negative effects. Qualitative analysis indicated a perceived improvement in outcome measures such as memory, attention, anxiety, and emotional control despite mixed quantitative findings whilst a clear impact of contextual factors, such as COVID-19, the political atmosphere, exercise tolerance, programme progression, and motivation were evident during the intervention. Conclusions This study has provided primary-level evidence to suggest active rehabilitation as a potential intervention for the management of suspected CTE symptoms. This study has also demonstrated the benefit of a person-centred approach to both clinical research and practice, particularly by considering contextual factors for a better understanding of an intervention effect.

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