Emerging therapies for fibromyalgia: an update

Ablin, Jacob N.; Buskila, Dan

doi:10.1517/14728214.2010.491509

Cited by 15 publications

(8 citation statements)

References 119 publications

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“…The CP represents an anatomically and physiologically parallel region of striatum that has not previously been implicated in partner preference formation. The involvement of the opiate system in the formation of adult social attachments is of particular importance as opioid antagonists, including NTX, are being used increasingly in humans as a treatment for alcoholism, opioid dependence, obesity, and fibromyalgia (Ablin and Buskila, 2010;Anacker and Ryabinin, 2010;Greenway et al, 2010;Lobmaier et al, 2010;Soyka and Rosner, 2010). Furthermore, the role of MOR in this behavior provides a vital link between the pair bonding literature and previous literature on maternal behavior, which further supports the hypothesis that the pair bonding circuitry evolved from the same mechanisms governing maternal behavior that are present in all mammals (Donaldson and Young, 2008).…”

Section: Resultsmentioning

confidence: 99%

Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles

Burkett

Spiegel

Inoue

et al. 2011

Neuropsychopharmacol

112

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Despite significant evidence that opioids are involved in attachment by mediating social reward and motivation, the role of opioids in the formation of adult social attachments has not been explored. We used the socially monogamous prairie vole (Microtus ochrogaster) to explore the role of endogenous opioids in social bonding by examining partner preference formation in female prairie voles. We hypothesized that m-opioid receptors (MORs) in the striatum have a critical role in partner preference formation. We therefore predicted that peripheral administration of an opioid receptor antagonist would inhibit partner preference formation, and more specifically, that m-opioid selective receptor blockade within the striatum would inhibit partner preference formation. To test our hypotheses, we first administered the non-selective opioid antagonist naltrexone peripherally to females during an 18-h cohabitation with a male and later tested the female with a partner preference test (PPT). Females showed a dose schedule-dependent decrease in partner preference in the PPT, with females in the continuous dose group displaying stranger preferences. Next, we administered microinjections of the MOR selective antagonist D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP) into either the nucleus accumbens shell (NAS) or the caudate-putamen (CP) immediately before a 24-h cohabitation with a male, and later tested the female with a PPT. Females receiving CTAP into the CP, but not the NAS, showed no preference in the PPT, indicating an inhibition of partner preference formation. We show here for the first time that MORs modulate partner preference formation in female prairie voles by acting in the CP.

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Section: Resultsmentioning

confidence: 99%

Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles

Burkett

Spiegel

Inoue

et al. 2011

Neuropsychopharmacol

112

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“…59,97 Using a mechanism-based approach to target-altered central processing of nociception rather than peripheral nociceptors may improve treatment. 98,99 Indeed SCS reduces sensitivity of dorsal horn neurons to noxious stimuli, 76 activates local and descending inhibitory pathways from the brainstem, 17,21,77 and uses the inhibitory neurotransmitters γ-aminobutyric acid, serotonin, and opioids to produce analgesia. [18][19][20][21][22][23][24][25][26][27][28] In addition, both 4 and 60 Hz SCS, in part, work through opioid receptor mechanisms, with 4 Hz SCS activating μ-opioid receptors while 60 Hz SCS activates δ-opioid receptors.…”

Section: Discussionmentioning

confidence: 99%

Spinal Cord Stimulation Reduces Mechanical Hyperalgesia and Restores Physical Activity Levels in Animals with Noninflammatory Muscle Pain in a Frequency-Dependent Manner

Gong

Johanek

Sluka

2014

Anesthesia &Amp; Analgesia

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“…135 Drugs such as ketamine that target Nmethyldaspartate receptors (which are present in activated microglia, as well as in dorsal horn transmission neurons) might also downregulate symptoms due to neuroinflammation in patients with fibromyalgia or CRPS, but no adequate trial evidence exists to support this approach. 136,137 Other drugs that target glutamate within the brain and spinal cord, such as memantine, might also downregulate neurogenic inflammation in fibromyalgia and CRPS. 19,138 Conclusions Neurogenic neuroinflammation is a key pathophysio logical mechanism in both fibromyalgia and CRPS.…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

2015

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Although fibromyalgia and complex regional pain syndrome (CRPS) have distinct clinical phenotypes, they do share many other features. Pain, allodynia and dysaesthesia occur in each condition and seem to exist on a similar spectrum. Fibromyalgia and CRPS can both be triggered by specific traumatic events, although fibromyalgia is most commonly associated with psychological trauma and CRPS is most often associated with physical trauma, which is frequently deemed routine or minor by the patient. Fibromyalgia and CRPS also seem to share many pathophysiological mechanisms, among which the most important are those involving central effects. Nonetheless, peripheral effects, such as neurogenic neuroinflammation, are also important contributors to the clinical features of each of these disorders. This Review highlights the differing degrees to which neurogenic neuroinflammation might contribute to the multifactorial pathogenesis of both fibromyalgia and CRPS, and discusses the evidence suggesting that this mechanism is an important link between the two disorders, and could offer novel therapeutic targets.

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Emerging therapies for fibromyalgia: an update

Cited by 15 publications

References 119 publications

Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles

Activation of μ-Opioid Receptors in the Dorsal Striatum is Necessary for Adult Social Attachment in Monogamous Prairie Voles

Spinal Cord Stimulation Reduces Mechanical Hyperalgesia and Restores Physical Activity Levels in Animals with Noninflammatory Muscle Pain in a Frequency-Dependent Manner

Neurogenic neuroinflammation in fibromyalgia and complex regional pain syndrome

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