Emerging Therapies in Penile Cancer

Alencar, Antonio Machado; Sonpavde, Guru

doi:10.3389/fonc.2022.910335

Cited by 4 publications

(4 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Penile cancer is a rare malignancy, and patients with this condition tend to delay seeking medical attention, which may lead to poor outcomes ( 55 ). Recent findings in penile cancer have motivated several trials evaluating new modalities of systemic treatments, especially immunotherapy ( 56 ). Sintilimab is a recombinant humanized lgG4 anti-PD-1 antibody, with affinity to human programmed cell death protein 1 (PD-1).…”

Section: Discussionmentioning

confidence: 99%

Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

Wang¹,

Shan²,

Zhou³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

Background Despite the rich proximity and vascularization to the pelvic organs, metastatic lesions to the penis are incredibly uncommon. Most primary tumors are genitourinary cancers, and rectal origins are rare. Only 56 cases of metastatic penile tumors have been reported since 1870. Several palliative or curative methods, such as chemotherapy, total penectomy, and radiotherapy, have been applied to treat this condition in previous cases; however, the patient prognosis is poor. Immunotherapy is a beneficial treatment approach for multiple cancers, and recent investigations have shown that it may be beneficial for patients with advanced penile cancer. Case Description Herein, we report the case of a 59-year-old Chinese man who had metastatic adenocarcinoma in the penile tissue 3 years after rectal cancer resection. The patient presented with penile pain and dysuria for 6 months when he was 54 years old, and Immunohistochemical staining showed that the origin was the rectum after total penectomy. The patient received surgery, chemotherapy, radiotherapy, targeted therapy and immunotherapy positively and still survived for a further 4 years and 6 months following penectomy despite the late metastasis of rectal cancer. There are two major changes and progress after penectomy, all of which have undergone surgical treatment during continuous treatment and follow-up, the patient completed right inguinal lymphadenectomy when his right regional nodes metastasis was found 23 months after penectomy. While the patient suffered from radiation injury after 47 months after penectomy, which led to radiation necrosis and hip soft tissue infection, and the patient tended to lay prone instead of lying on the back because of the hip pain. The patient ultimately died of multiple organ failure. Conclusions All of the previously reported cases of penile metastasis from rectal cancer since 1870 have been reviewed. Yet, the metastatic prognosis remains poor regardless of the treatment options, except for lesions where metastasis is only limited to the penis. We found that the patient may derive more benefit from strategic therapies including surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

Wang¹,

Shan²,

Zhou³

et al. 2023

J Gastrointest Oncol

View full text Add to dashboard Cite

show abstract

“…Current estimates suggest that 30-50% of cases are associated with high-risk human papillomavirus (HPV) infection [3], which diversifies the underlying oncogenic machinery contributing to carcinogenesis and disease progression. Limited effective treatment options are available when the disease is locally advanced or refractory to surgical resection, chemoradiation, or first-line chemotherapy [4]. Despite this limitation, targeted therapy has not become a mainstay in PSCC given the rarity of the disease, patient exclusion from most clinical trials, and lack of robust disease models to facilitate translational research [5,6].…”

Section: Introductionmentioning

confidence: 99%

An Assessment of the Penile Squamous Cell Carcinoma Surfaceome for Biomarker and Therapeutic Target Discovery

Grass

Ercan

Obermayer

et al. 2023

Cancers

View full text Add to dashboard Cite

Penile squamous cell carcinoma (PSCC) is a rare malignancy in most parts of the world and the underlying mechanisms of this disease have not been fully investigated. About 30–50% of cases are associated with high-risk human papillomavirus (HPV) infection, which may have prognostic value. When PSCC becomes resistant to upfront therapies there are limited options, thus further research is needed in this venue. The extracellular domain-facing protein profile on the cell surface (i.e., the surfaceome) is a key area for biomarker and drug target discovery. This research employs computational methods combined with cell line translatomic (n = 5) and RNA-seq transcriptomic data from patient-derived tumors (n = 18) to characterize the PSCC surfaceome, evaluate the composition dependency on HPV infection, and explore the prognostic impact of identified surfaceome candidates. Immunohistochemistry (IHC) was used to validate the localization of select surfaceome markers. This analysis characterized a diverse surfaceome within patient tumors with 25% and 18% of the surfaceome represented by the functional classes of receptors and transporters, respectively. Significant differences in protein classes were noted by HPV status, with the most change being seen in transporter proteins (25%). IHC confirmed the robust surface expression of select surfaceome targets in the top 85% of expression and a superfamily immunoglobulin protein called BSG/CD147 was prognostic of survival. This study provides the first description of the PSCC surfaceome and its relation to HPV infection and sets a foundation for novel biomarker and drug target discovery in this rare cancer.

show abstract

“…It is a rare malignant tumour, more common in developing countries than in developed ones [2]. In 2020, the number of people suffering from penile cancer worldwide was 36 068 (0.92 cases/100 000 people) [3]. In Poland, in 2020 penile cancer was diagnosed in 273 men, which gave the standardized incidence rate of 0.8 cases/100 000 people [4].…”

Section: Introductionmentioning

confidence: 99%

“…Surgical methods and chemotherapy are the most relevant in the treatment of penile cancer [3]. Regardless of the method used, it often leads to serious consequences, including disturbances in the patient's body image and functioning [1].…”

Section: Introductionmentioning

confidence: 99%

Acceptance of illness and satisfaction with the life of the patient after penectomy

Sraga,

Zmarlak,

Szajnowska

et al. 2023

Palliat Med Pract

View full text Add to dashboard Cite

Penile cancer is a rare malignant neoplasm, occurring mainly in men in their sixties and seventies. The consequences of treatment often include a severely disturbed perception of one's body image, lowered self-esteem and difficulties in daily functioning, which can result in reduced satisfaction with further life. This study aimed to assess the life satisfaction and level of acceptance of illness of a 42-year-old patient after penectomy in the course of cancer. The following tools were applied in the study: the authors' own questionnaire, the Acceptance of Illness Scale (AIS) and the Satisfaction With Life Scale (SWLS). The patient surveyed scored 38 out of 40 on the AIS scale, indicating that he accepted his illness, while on the SWLS scale, he scored the maximum number of points indicating a high overall sense of satisfaction with life. The patient did not report any difficulties in terms of daily functioning resulting from the diagnosed disease and the treatment administered.

show abstract

Emerging Therapies in Penile Cancer

Cited by 4 publications

References 76 publications

Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

Surgery, radiotherapy, chemotherapy, targeted therapy, and immunotherapy of rectal adenocarcinoma with penile metastasis: a case report

An Assessment of the Penile Squamous Cell Carcinoma Surfaceome for Biomarker and Therapeutic Target Discovery

Acceptance of illness and satisfaction with the life of the patient after penectomy

Contact Info

Product

Resources

About