Emerging Topics in Atherosclerosis: HDL Raising Therapies

Improved Synthesis and Crystal Structure of Dalcetrapib

“…Cholesteryl Ester Transfer Protein (CETP) inhibitors [1] are investigated as high density lipoprotein-cholesterol (HDL-C) raising agents with beneficial effects on atherosclerosis. A series of S- (2-(acylamino)phenyl) alkanethioates was evaluated, and S- (2-((1-(2-ethylbutyl)cyclohexane) carbonyl-amino)phenyl) 2-methylpropanethioate was found to exhibit significant inhibition of CETP activity in animals [2,3] and clinical trials [4,5].…”