Emerging Trajectories for Next Generation Tissue Engineers

Tavakol, Daniel Naveed; Fleischer, Sharon; Falcucci, Thomas; Graney, Pamela L.; Halligan, Susan P.; Kaplan, David L.; Vunjak-Novakovic, Gordana

doi:10.1021/acsbiomaterials.1c01428

Cited by 7 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings suggest early hypertrophy of the muscle after irradiation, consistent with increased expression of hypertrophy-related genes (26). In bone marrow, there was a dose-dependent decrease in CD45 þ blood cell number after exposures to photon and neutron radiation, suggesting reduced cell proliferation, with greater effect of neutron relative to photon radiation.…”

Section: Session I: Microphysiological Systems and Chip Technologiesmentioning

confidence: 55%

“…Work has also been performed with a chip containing heart and bone marrow tissues, each in isolation, to examine the effects of neutron and photon radiation (26). Neutrons were used to simulate the high-LET component of the GCR spectrum, as they are relevant to space travel, and neutrons are generated as secondary radiation when GCR hits the surface of the Moon or spaceship shielding (19).…”

Section: Session I: Microphysiological Systems and Chip Technologiesmentioning

confidence: 99%

See 1 more Smart Citation

Advanced Technologies in Radiation Research

Rios,

DiCarlo,

Harrison

et al. 2024

Radiation Research

View full text Add to dashboard Cite

The U.S. Government is committed to maintaining a robust research program that supports a portfolio of scientific experts who are investigating the biological effects of radiation exposure. On August 17 and 18, 2023, the Radiation and Nuclear Countermeasures Program, within the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), partnered with the National Cancer Institute, NIH, the National Aeronautics and Space Administration, and the Radiation Injury Treatment Network to convene a workshop titled, Advanced Technologies in Radiation Research (ATRR), which focused on the use of advanced technologies under development or in current use to accelerate radiation research. This meeting report provides a comprehensive overview of the research presented at the workshop, which included an assembly of subject matter experts from government, industry, and academia. Topics discussed during the workshop included assessments of acute and delayed effects of radiation exposure using modalities such as clustered regularly interspaced short palindromic repeats (CRISPR) – based gene editing, tissue chips, advanced computing, artificial intelligence, and immersive imaging techniques. These approaches are being applied to develop products to diagnose and treat radiation injury to the bone marrow, skin, lung, and gastrointestinal tract, among other tissues. The overarching goal of the workshop was to provide an opportunity for the radiation research community to come together to assess the technological landscape through sharing of data, methodologies, and challenges, followed by a guided discussion with all participants. Ultimately, the organizers hope that the radiation research community will benefit from the workshop and seek solutions to scientific questions that remain unaddressed. Understanding existing research gaps and harnessing new or re-imagined tools and methods will allow for the design of studies to advance medical products along the critical path to U.S. Food and Drug Administration approval.

show abstract

Section: Session I: Microphysiological Systems and Chip Technologiesmentioning

confidence: 55%

Section: Session I: Microphysiological Systems and Chip Technologiesmentioning

confidence: 99%

Advanced Technologies in Radiation Research

Rios,

DiCarlo,

Harrison

et al. 2024

Radiation Research

View full text Add to dashboard Cite

show abstract

“…Three-dimensional printing technology allows for the precise control of nanoparticle distribution within the scaffold, resulting in improved tissue regeneration and repair. Hence, tissue engineering involves creating functional biological tissues by combining cells, biomaterials, and biochemical cues [240]. Three-dimensional printing has enabled the fabrication of complex and customized scaffolds with high accuracy and precision, making it a promising tool for tissue engineering applications [241].…”

Section: Regeneration Applicationsmentioning

confidence: 99%

Promising New Horizons in Medicine: Medical Advancements with Nanocomposite Manufacturing via 3D Printing

Li,

Khan,

Chen

et al. 2023

Polymers

View full text Add to dashboard Cite

Three-dimensional printing technology has fundamentally revolutionized the product development processes in several industries. Three-dimensional printing enables the creation of tailored prostheses and other medical equipment, anatomical models for surgical planning and training, and even innovative means of directly giving drugs to patients. Polymers and their composites have found broad usage in the healthcare business due to their many beneficial properties. As a result, the application of 3D printing technology in the medical area has transformed the design and manufacturing of medical devices and prosthetics. Polymers and their composites have become attractive materials in this industry because of their unique mechanical, thermal, electrical, and optical qualities. This review article presents a comprehensive analysis of the current state-of-the-art applications of polymer and its composites in the medical field using 3D printing technology. It covers the latest research developments in the design and manufacturing of patient-specific medical devices, prostheses, and anatomical models for surgical planning and training. The article also discusses the use of 3D printing technology for drug delivery systems (DDS) and tissue engineering. Various 3D printing techniques, such as stereolithography, fused deposition modeling (FDM), and selective laser sintering (SLS), are reviewed, along with their benefits and drawbacks. Legal and regulatory issues related to the use of 3D printing technology in the medical field are also addressed. The article concludes with an outlook on the future potential of polymer and its composites in 3D printing technology for the medical field. The research findings indicate that 3D printing technology has enormous potential to revolutionize the development and manufacture of medical devices, leading to improved patient outcomes and better healthcare services.

show abstract

“…Over the last century, tissue engineering has emerged as a crucial research field and a hotspot in regenerative medicine, interweaving multiple disciplines such as life science, material science, and engineering. The field has yielded a plethora of tissue engineering products that are being employed in clinical applications to repair damaged tissues and organs [1]. With the increasing prevalence of vascular-related diseases, the development of tissue-engineered scaffold tailored for vascular reconstruction and regeneration is a pressing concern.…”

Section: Introductionmentioning

confidence: 99%

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Wang

Feng

2023

Gels

View full text Add to dashboard Cite

Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds, mainly due to the advantages of their chemical and physical properties. This review focuses on the application of chitosan hydrogels in tissue engineering scaffolds for vascular regeneration. We have mainly introduced these following aspects: advantages and progress of chitosan hydrogels in vascular regeneration hydrogels and the modification of chitosan hydrogels to improve the application in vascular regeneration. Finally, this paper discusses the prospects of chitosan hydrogels for vascular regeneration.

show abstract

Emerging Trajectories for Next Generation Tissue Engineers

Cited by 7 publications

References 29 publications

Advanced Technologies in Radiation Research

Advanced Technologies in Radiation Research

Promising New Horizons in Medicine: Medical Advancements with Nanocomposite Manufacturing via 3D Printing

Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications

Contact Info

Product

Resources

About