2017
DOI: 10.1002/art.40168
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Emerging Treatment Models in Rheumatology: IgG4‐Related Disease: Insights Into Human Immunology and Targeted Therapies

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Cited by 52 publications
(29 citation statements)
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References 66 publications
(162 reference statements)
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“…IgG4 antibodies are poor binders to Fc receptors and complement and they are not usually able to crosslink antigen or form immune complexes due to Fab-arm exchange. Therefore, for the most part, they are thought to blunt the inflammatory response resulting from chronic antigenic exposure by competing with other IgG subclasses to bind antigen at sites of inflammation (35).…”
Section: Discussionmentioning
confidence: 99%
“…IgG4 antibodies are poor binders to Fc receptors and complement and they are not usually able to crosslink antigen or form immune complexes due to Fab-arm exchange. Therefore, for the most part, they are thought to blunt the inflammatory response resulting from chronic antigenic exposure by competing with other IgG subclasses to bind antigen at sites of inflammation (35).…”
Section: Discussionmentioning
confidence: 99%
“…IgG4 related disease (IgG4 RD), a unifying term for a number of previously recognized organ specific diseases (eg, Riedel's thyroiditis, autoimmune sclerosing pancreatitis and others), is a rare, multisystem chronic inflammatory disorder of unknown etiology. It is characterized by tumefactive inflammatory lesions often affecting the hepatobiliary tree, the salivary glands, the lacrimal glands/orbits, lymph nodes and less commonly other organs including the skin.…”
Section: Plasmacytic Infiltrates In the Skin—inflammatorymentioning
confidence: 99%
“…Although etiologic factors often remain elusive, clarification of disease mechanisms has emerged. For example, the causes of systemic plasmacytosis, multicentric Castleman's disease and IgG4‐related disease are unknown but many of the relevant inflammatory pathways have been identified . This has helped to hone therapeutic strategies.…”
Section: Advances In Our Understanding Of Lymphoplasmacytic Pathologymentioning
confidence: 99%
See 1 more Smart Citation
“…1 Interstitial fibrosis and vein lesions are lacking in some anatomic sites (eg, lymph nodes), making the diagnosis of IgG4-RD a true challenge. [1][2][3] Despite the vast majority of IgG4-RD has been reported in adults, 4 this condition is increasingly documented also in the pediatric population. To date, 36 cases of childhood IgG4-RD have been published, most of which encompass solid lesions in extra-nodal sites.…”
Section: Pediatric Igg4-related Lymphadenopathy: a Rare Condition Assmentioning
confidence: 99%