Emerging treatments for chronic urticaria

Wedi, Bettina

doi:10.1080/13543784.2022.2042513

Cited by 16 publications

(15 citation statements)

References 90 publications

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“…Various therapies, targeting mediators, receptors and signalling pathways of mast and other immune cells, are in preclinical and clinical development 13,164,[204][205][206] (Fig. 3; all ongoing studies are listed in Table 3).…”

Section: Therapies In Developmentmentioning

confidence: 99%

Urticaria

Kolkhir

Giménez‐Arnau

Kulthanan

et al. 2022

Nat Rev Dis Primers

185

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Section: Therapies In Developmentmentioning

confidence: 99%

Urticaria

Kolkhir

Giménez‐Arnau

Kulthanan

et al. 2022

Nat Rev Dis Primers

185

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“…Increased rs-FC between the mPFtha and dlPFC on the right side may suggest pruritus-induced sensory hypersensitivity in patients with CSU. The pruritus cycle is the most concentrated manifestation of chronic pruritus and is regulated by multiple brain networks ( Wedi, 2022 ). By comprehensively observing the changes in the clinical symptom score (UAS7) and immune index (IgE), the pathological changes in brain function in patients with CSU can be described in more detail.…”

Section: Discussionmentioning

confidence: 99%

Functional connectivity impairment of thalamus-cerebellum-scratching neural circuits in pruritus of chronic spontaneous urticaria

Zhang

Zou²,

Yu³

et al. 2022

Front. Neurosci.

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Pruritus of chronic spontaneous urticaria (CSU) is one of the most common and irritating sensations that severely affects the quality of life. However, the changes in the functional connectivity (FC) between thalamic subregions and other brain regions have not been fully elucidated. This study aimed to explore the potential changes in brain neural circuits by focusing on various subregions of the thalamus in patients with CSU pruritus to contribute to the understanding of chronic pruritus from the perspective of central mechanisms. A total of 56 patients with CSU and 30 healthy controls (HCs) completed the data analysis. Urticaria Activity Score 7 (UAS7), pruritus visual analog score (VAS-P), Dermatological Life Quality Index (DLQI), and immunoglobulin E (IgE) values were collected to assess clinical symptoms. Seed-based resting-state functional connectivity (rs-FC) analysis was used to assess relevant changes in the neural circuits of the brain. Compared to HCs, seeds within the caudal temporal thalamus (cTtha) on the right side of patients with CSU showed increased rs-FC with the cerebellum anterior lobe (CAL). Seeds within the lateral prefrontal thalamus (lPFtha) on the right side showed increased rs-FC with both CAL and pons, while those within the medial prefrontal thalamus (mPFtha) on the right side showed increased rs-FC with both CAL and the dorsal lateral prefrontal cortex (dlPFC) on the right side. Seeds within the posterior parietal thalamus (PPtha) on the right side showed increased rs-FC with the cerebellum posterior lobe (CPL) on the left side. The UAS7 values and IgE levels were positively correlated with the rs-FC of the right dlPFC. Our results suggest that patients with CSU may exhibit stronger rs-FC alterations between certain thalamic subregions and other brain regions. These changes affect areas of the brain involved in sensorimotor and scratching.Trial registration number[http://www.chictr.org.cn], identifier [ChiCTR1900022994].

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“…But cost effective and maintenance parameters are not in favour of using in poor patients . [21,22] The omalizumab treatment currently best option for chronic urticaria which is resistant to antihistaminics. In ASST positive urticaria usage of omalizumab does show any significant difference in therapeutics response compared to ASST negative patients .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of autologous serum therapy in ASST positive and ASST negative patients in chronic urticaria in a tertiary care centre

Raghavendra

Bangaru

2022

Dermatol Reports

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Background: Autologous Serum Therapy (AST) has been a recent therapeutic choice for a variety of chronic diseases such as allergic, inflammatory, infectious, and autoimmune disorders, however evidence were not convincing the beneficial effects of autologous serum therapy in treatment of Chronic urticaria. Chronic Urticaria (CU) is common dermatological condition and very disturbing to the patient as well as physician. A new observation was made about the abnormal type 1 reactions to intradermal autologous serum injections in some CU patients. This has led to the new subgroup of “autoimmune chronic urticaria”. The autologous serum skin test (ASST) it is an intradermal test result in immediate hypersensitivity-type skin reactions in a subpopulation of CU patients and giving promising evidence of therapeutic and diagnostic benefit. Already autologous whole blood (AWB) injection has been used as one of old treatment modalities for chronic urticaria. Objectives: To study the efficacy of autologous serum therapy in patients with chronic urticaria & compare its results in ASST(+) & ASST(-) chronic urticaria patients. Methodology: Approximately 5ml of patients’ blood was drawn in a plain vacutainer and centrifuged at 3000 r.p.m. for 10 min, separated 2.5 ml serum injected deep intramuscularly into gluteus muscle & injections were repeated every week for about 9 weeks & a repeat follow up at 20 weeks was done. Results: Out of total 20 patients excellent improvement seen in 6 patients in terms of decrease in Urticaria assessment severity score whereas ten patients showed partial response and two patients showed no response & two patients lost follow up. Ten patients with ASST (+) & six patients of ASST(-) showed little improvement in urticaria severity score. Conclusion: AST therapy is a cost-effective adjuvant modality for reducing the severity of symptoms of chronic urticaria. In some patients its giving long term remission period and it decreases the updosing of antihistamines.

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Emerging treatments for chronic urticaria

Cited by 16 publications

References 90 publications

Urticaria

Urticaria

Functional connectivity impairment of thalamus-cerebellum-scratching neural circuits in pruritus of chronic spontaneous urticaria

Efficacy of autologous serum therapy in ASST positive and ASST negative patients in chronic urticaria in a tertiary care centre

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