Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future

Kheradvar, Arash; Groves, Elliott M.; Dasi, Lakshmi Prasad; Alavi, S. Hamed; Tranquillo, Robert T.; Grande-Allen, K. Jane; Simmons, Craig A.; Griffith, Boyce E.; Falahatpisheh, Ahmad; Goergen, Craig J.; Mofrad, Mohammad R. K.; Baaijens, Fpt Frank; Little, Stephen H.; Čanić, Sunčica

doi:10.1007/s10439-014-1209-z

Cited by 82 publications

(73 citation statements)

References 102 publications

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“…Thus, calling r 0 the microstructure vector at the (n − 1)th iteration, the vector a 0 at the nth iteration was obtained by (10) where R 0 represents the rotation matrix, defined from the angle between the vector r 0 and the maximum principal stress direction in the (n − 1)th iteration (Fig. 3).…”

Section: Materials Microstructure Optimizationmentioning

confidence: 99%

“…Yet, no PHV is currently used in clinical practice; several PHV prototypes, mainly composed of polyurethane-based materials, have been developed since 1960s [1] but, despite their promising short-term outcomes [2][3][4][5][6], none have shown satisfactory long-term reliability, due primarily to calcification and tearing of the leaflets [7][8][9][10]. The achievement of an adequate device lifetime remains the main challenge in the development of a clinically viable polymeric prosthesis.…”

Section: Introductionmentioning

confidence: 99%

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A Computational Tool for the Microstructure Optimization of a Polymeric Heart Valve Prosthesis

Serrani

Brubert

Stasiak

et al. 2016

Journal of Biomechanical Engineering

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Styrene-based block copolymers are promising materials for the development of a polymeric heart valve prosthesis (PHV), and the mechanical properties of these polymers can be tuned via the manufacturing process, orienting the cylindrical domains to achieve material anisotropy. The aim of this work is the development of a computational tool for the optimization of the material microstructure in a new PHV intended for aortic valve replacement to enhance the mechanical performance of the device. An iterative procedure was implemented to orient the cylinders along the maximum principal stress direction of the leaflet. A numerical model of the leaflet was developed, and the polymer mechanical behavior was described by a hyperelastic anisotropic constitutive law. A custom routine was implemented to align the cylinders with the maximum Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts principal stress direction in the leaflet for each iteration. The study was focused on valve closure, since during this phase the fibrous structure of the leaflets must bear the greatest load. The optimal microstructure obtained by our procedure is characterized by mainly circumferential orientation of the cylinders within the valve leaflet. An increase in the radial strain and a decrease in the circumferential strain due to the microstructure optimization were observed. Also, a decrease in the maximum value of the strain energy density was found in the case of optimized orientation; since the strain energy density is a widely used criterion to predict elastomer's lifetime, this result suggests a possible increase of the device durability if the polymer microstructure is optimized. The present method represents a valuable tool for the design of a new anisotropic PHV, allowing the investigation of different designs, materials, and loading conditions. Keywordspolymeric heart valve; heart valve prosthesis; computational modeling

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Section: Materials Microstructure Optimizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Computational Tool for the Microstructure Optimization of a Polymeric Heart Valve Prosthesis

Serrani

Brubert

Stasiak

et al. 2016

Journal of Biomechanical Engineering

View full text Add to dashboard Cite

show abstract

“…Another area of polymers' application is the gradual substitution of the implanted bioresorbable scaffold for vascular (stent) of the normal There are also isolated examples of the stents made of completely destructible materials (polylactides, polyurethanes, and silicone) [15].…”

Section: Matarneh Et Almentioning

confidence: 99%

“…Both the synthetic biostable and biodegraded polymers are applied as constructional materials to extracorporeal devices [14,15].…”

Section: Matarneh Et Almentioning

confidence: 99%

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Polymers in Cardiovascular Surgery

Matarneh

Sotnik

Lyashenko

2018

Asian J Pharm Clin Res

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Surgical intervention is still one of the most important treatment methods to investigate or treat a pathological condition, and the cardiovascular surgery is considered one of the most important types of surgical interventions at all. The uniqueness of a human body and the impossibility of its full procreation, enforces the use of various auxiliary materials such as polymers to carry out the most difficult surgery while ensuring further vital activity. In this paper, we explore the features of polymers which are used in cardiovascular surgery, discussing the existing variety of such polymers and the orientations of their use. Depending on the carried out analysis, the classification of main types of polymers had been offered which are the most suitable for cardiovascular surgery, besides generalized classification of polymeric products defects. The obtained results enable to immediately identify all significant factors that may lead to emergence defect for the purpose of its control and prevention to improve the quality of surgical intervention and stabilize the patient's cardiovascular system.

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Silk Sericin is a Potent, Multifunctional Biomaterial for Endothelialization of Tissue‐Engineered Heart Valves

Song,

Wang,

et al. 2024

Adv Funct Materials

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Endothelialization is important for offering an anticoagulant surface, which is crucial for the construction of tissue‐engineered heart valves. Silk sericin is extensively investigated in the biomedical field due to its remarkable biological activities and diverse functional groups, favoring chemical modifications for the formation of versatile constructs. Herein, a sericin covalently modified valve (SCMV) is successfully fabricated by coupling maleylated silk sericin (MSS) with thiolated decellularized heart valve (DHV) through a Michael addition reaction. The results demonstrate that SCMV exhibits a smooth surface, higher hydrophilicity, and excellent resistance to platelets adhesion compared to DHV. Additionally, SCMV promotes endothelial cells (ECs) adhesion under both static and flow conditions and enhances their survival in a mouse subcutaneous implant model. The study also discovered that MSS‐stimulated ECs exhibit increased RhoA activation, expression of rho‐associated protein kinase 2 (ROCK2) and phosphorylated myosin light chain 2 (MLC2), actin polymerization, and cell adhesion; whereas actin organization and cell adhesion are significantly reduced by treatment with Y‐27632, a ROCK inhibitor. Furthermore, several integrin subunits, including α1, α2, α3, α5, α6, β1, β3, and β5, are involved in this regulatory process. Collectively, the findings highlight the potential application of silk sericin in promoting endothelialization of DHV while uncovering novel mechanisms underlying its regulatory effect on ECs adhesion.

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Emerging Trends in Heart Valve Engineering: Part I. Solutions for Future

Cited by 82 publications

References 102 publications

A Computational Tool for the Microstructure Optimization of a Polymeric Heart Valve Prosthesis

A Computational Tool for the Microstructure Optimization of a Polymeric Heart Valve Prosthesis

Polymers in Cardiovascular Surgery

Silk Sericin is a Potent, Multifunctional Biomaterial for Endothelialization of Tissue‐Engineered Heart Valves

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