Emerging trends in production of plant natural products and new-to-nature biopharmaceuticals in yeast

Perrot, Thomas; Marc, Jillian; Lezin, Enzo; Papon, Nicolas; Besseau, Sébastien; Courdavault, Vincent

doi:10.1016/j.copbio.2024.103098

Current Opinion in Biotechnology

2024

DOI: 10.1016/j.copbio.2024.103098

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Emerging trends in production of plant natural products and new-to-nature biopharmaceuticals in yeast

Thomas Perrot,

Jillian Marc,

Enzo Lezin

et al.

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Advances in genome engineering and associated technologies have reinvigorated natural products research. Here we highlight the latest developments in the field across the discover− design−build−test−learn cycle of bioengineering, from recent progress in computational tools for AI-supported genome mining, enzyme and pathway engineering, and compound identification to novel host systems and new techniques for improving production levels, and place these trends in the context of responsible research and innovation, emphasizing the importance of anticipatory analysis at the early stages of process development.

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Vaccine-enhancing plant extract could be mass produced in yeast

Nett

2024

Nature

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Emerging trends in production of plant natural products and new-to-nature biopharmaceuticals in yeast

Cited by 4 publications

References 54 publications

Editorial overview: Chemical biotechnology paving the way for a sustainable future

Editorial overview: Chemical biotechnology paving the way for a sustainable future

Synthetic Biology of Natural Products Engineering: Recent Advances Across the Discover–Design–Build–Test–Learn Cycle

Vaccine-enhancing plant extract could be mass produced in yeast

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