Emerging Trends in Quinolone Resistance among Urinary Pathogens: A Brief Review

Abstract

Urinary tract infections (UTIs) present a significant global health challenge, Intensified by the high level of antimicrobial resistance, particularly to quinolone antibiotics. This brief review synthesizes recent literature to elucidate the prevalence and mechanisms of quinolone resistance, with a focus on plasmid-mediated quinolone resistance (PMQR), among UTI-causing pathogens. Highlighting the genetic basis of resistance, including mutations in DNA gyrase and efflux pump regulation genes, as well as the role of plasmid-mediated mechanisms such as 'qnr' genes, the review underscores the clinical implications of quinolone resistance in UTI management. Understanding these emerging trends is urgently required for improving antimicrobial management strategies and guiding effective interventions to control the spread of quinolone resistance among urinary pathogens.