Emerging trends of invasive yeast infections and azole resistance in Beijing intensive care units

Yu, J.; Yang, W.; Fan, X.; Cui, E.; Min, R.; Yuan, H.; Hu, Y.; Wang, H.; Zhang, G.; Zhao, Y.; Xu, Y.; Guo, L.

doi:10.1016/j.jhin.2024.04.020

Journal of Hospital Infection

2024

DOI: 10.1016/j.jhin.2024.04.020

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Emerging trends of invasive yeast infections and azole resistance in Beijing intensive care units

J. Yu,

W. Yang,

X. Fan

et al.

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Candida glabrata: A Tale of Stealth and Endurance

Askari,

Kaur

2024

ACS Infect. Dis.

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Candida (Nakaseomyces) glabrata, an opportunistic human fungal pathogen, causes mucosal and deep-seated infections in immunocompromised individuals. Recently designated as a highpriority fungal pathogen by the World Health Organization (WHO), C. glabrata exhibits low inherent susceptibility to azole antifungals. In addition, about 10% clinical isolates of C. glabrata display co-resistance to both azole and echinocandin drugs. Molecular mechanisms of antifungal resistance and virulence in C. glabrata are currently being delineated in-depth. This Review provides an overview of the epidemiology, biology, drug resistance, tools and host model systems for C. glabrata. Additionally, we discuss the immune evasion strategies that aid C. glabrata in establishing infections in the host. Overall, this Review aims to contribute to ongoing efforts to raise awareness of human pathogenic fungi, the growing threat of antifungal drug resistance and the unmet need for novel antifungal therapies, with an ultimate goal of improving clinical outcomes of affected individuals.

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Candida glabrata: A Tale of Stealth and Endurance

Askari,

Kaur

2024

ACS Infect. Dis.

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scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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Emerging trends of invasive yeast infections and azole resistance in Beijing intensive care units

Cited by 1 publication

References 37 publications

Candida glabrata: A Tale of Stealth and Endurance

Candida glabrata: A Tale of Stealth and Endurance

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