Emerging trends of nanobiomaterials in hard tissue engineering

Khambete, Hemant; Keservani, Raj K.; Kesharwani, Rajesh K.; Jain, Nishi; Jain, C. L.

doi:10.1016/b978-0-323-42862-0.00003-1

Cited by 7 publications

(4 citation statements)

References 198 publications

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“…This method can control the polymer surface structure, including surface heterogeneity and reorientation of the surface crystal [82,83]. This technique was frequently used to manufacture 2D structures and various 3D Structures in a short period.…”

Section: Solvent Casting and Particulate Leachingmentioning

confidence: 99%

"Nano, Micro, and Macro Materials in Scaffolds for Biomedical Applications: A Review"

Sathish

2022

BJSTR

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Nano, micro, and macro materials for bio-functional scaffolds have garnered more attention in the past few years owing to their ability to mimic the natural environment of the body tissue that needs a repair or replacement accordingly. Although micro structured materials were used in tissue engineering in different forms, the emergence of nanomaterials has enabled the development of nanostructured biomedical scaffolds. The nanostructured scaffolds show enhanced biological functions and properties than micro structured scaffolds. For example, nanostructured scaffolds have a higher surface area, thus allowing better cell adhesion than other conventional materials used in tissue engineering. In addition, the nanomaterials have a significant advantage of mimicking and resembling the natural Extra Cellular Matrix (ECM), which provides better protein absorption, thus stimulating improved tissue engineering. This review presents the different nano, micro, and macro biomaterials employed in developing nanostructured scaffolds and their fabrication techniques. In addition, different types of nanostructured scaffolds used in tissue engineering are elucidated.

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Section: Solvent Casting and Particulate Leachingmentioning

confidence: 99%

"Nano, Micro, and Macro Materials in Scaffolds for Biomedical Applications: A Review"

Sathish

2022

BJSTR

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“…A scaffold is an artificial structure capable of supporting three-dimensional tissue formation that allows cell attachment and migration, delivery of biochemical factors, and diffusion of vital cell nutrients and expressed products. 51 An ideal scaffold possesses the following characteristics: 73 1. Three-dimensionality and high porosity with an interconnected pore network for cell growth and flow transport of nutrients and metabolic waste;…”

Section: Scaffoldsmentioning

confidence: 99%

“…Broadly, a growth factor can be defined as a protein that affects cell migration, proliferation, and differentiation. 51 Growth factors have short half-lives and diffuse slowly through the ECM to act locally. 52 Cell proliferation, ECM synthesis, vascularization, as well as mechanical properties can be dramatically influenced by the presence of growth factors.…”

Section: Growth Factorsmentioning

confidence: 99%

Bioaugmentation in the surgical treatment of anterior cruciate ligament injuries: A review of current concepts and emerging techniques

et al. 2020

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Injuries involving the anterior cruciate ligament are among the most common athletic injuries, and are the most common involving the knee. The anterior cruciate ligament is a key translational and rotational stabilizer of the knee joint during pivoting and cutting activities. Traditionally, surgical intervention in the form of anterior cruciate ligament reconstruction has been recommended for those who sustain an anterior cruciate ligament rupture and wish to remain active and return to sport. The intra-articular environment of the anterior cruciate ligament makes achieving successful healing following repair challenging. Historically, results following repair were poor, and anterior cruciate ligament reconstruction emerged as the gold-standard for treatment. While earlier literature reported high rates of return to play, the results of more recent studies with longer follow-up have suggested that anterior cruciate ligament reconstruction may not be as successful as once thought: fewer athletes are able to return to sport at their preinjury level, and many still go on to develop osteoarthritis of the knee at a relatively younger age. The four principles of tissue engineering (cells, growth factors, scaffolds, and mechanical stimuli) combined in various methods of bioaugmentation have been increasingly explored in an effort to improve outcomes following surgical treatment of anterior cruciate ligament injuries. Newer technologies have also led to the re-emergence of anterior cruciate ligament repair as an option for select patients. The different biological challenges associated with anterior cruciate ligament repair and reconstruction each present unique opportunities for targeted bioaugmentation strategies that may eventually lead to better outcomes with better return-to-play rates and fewer revisions.

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“…The use of bioinductive implants has emerged as a promising option in orthopedic surgery to facilitate healing and enhance the strength of tissue repair [8]. These implants act as an artificial structure capable of supporting threedimensional tissue formation that allows for cell attachment and migration, delivery of biochemical factors, and diffusion of cell nutrients to improve the local tissue environment and promote healing [8][9]. The implants are minimally cross-linked and freeze-dried and are designed to gradually undergo degradation within six months, leaving a layer of new tendon-like tissue; this new tissue decreases peak strain, thereby creating an environment conducive to healing [10].…”

Section: Introductionmentioning

confidence: 99%

Bioinductive Collagen Implant Augmentation for the Repair of Chronic Lower Extremity Tendinopathies: A Report of Two Cases

Looney¹,

Fortier²,

Leider³

et al. 2021

Cureus

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In this report, we present two cases of refractory chronic lower extremity tendinopathies treated with collagen bioinductive implant augmentation: a 20-year-old male football player with chronic patellar tendinopathy and a 40-year-old active female with chronic proximal hamstring tendinopathy. We demonstrate that bioaugmentation may represent an effective strategy in the surgical treatment of chronic tendinopathies. Both patients were able to return to their pre-injury activity levels at an accelerated rate.

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Emerging trends of nanobiomaterials in hard tissue engineering

Cited by 7 publications

References 198 publications

"Nano, Micro, and Macro Materials in Scaffolds for Biomedical Applications: A Review"

"Nano, Micro, and Macro Materials in Scaffolds for Biomedical Applications: A Review"

Bioaugmentation in the surgical treatment of anterior cruciate ligament injuries: A review of current concepts and emerging techniques

Bioinductive Collagen Implant Augmentation for the Repair of Chronic Lower Extremity Tendinopathies: A Report of Two Cases

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