Emerging ultrasonic bioelectronics for personalized healthcare

Jiang, Laiming; Wu, Jiagang

doi:10.1016/j.pmatsci.2023.101110

Cited by 30 publications

(13 citation statements)

References 273 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(ii) A dual-channel US system to produce biphasic stimulus waveform through the manipulation of US frequency. Previous piezoelectric stimulators were mostly monopolar stimuli 23 , 31 , 42 , 45 . However, a biphasic stimulus is usually required for biomedical stimulators, especially for some high-frequency stimulations, since its charge balance waveform reduces charge buildup and undesirable electrochemical reactions on the electrode surface 41 , 46 , 47 .…”

Section: Resultsmentioning

confidence: 99%

“…This is because, for monophasic stimulation with charge imbalance, the accumulated charges on the stimulating electrodes may lead to electrolysis, which can cause tissue damage or electrode damage 40 , 41 . However, current US implants typically deliver monophasic stimulus pulses in the absence of complex analog and digital circuits due to single-frequency operation 23 , 31 , 42 . Whereas, the use of complex analog and digital circuits poses challenges to device miniaturization due to the deployment of multiple components, rendering it unfavorable for implantable applications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation

Wang,

Zhang,

Xue

et al. 2024

Nat Commun

Self Cite

View full text Add to dashboard Cite

Ultrasound-driven bioelectronics could offer a wireless scheme with sustainable power supply; however, current ultrasound implantable systems present critical challenges in biocompatibility and harvesting performance related to lead/lead-free piezoelectric materials and devices. Here, we report a lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation, which integrates two developed lead-free sandwich porous 1-3-type piezoelectric composite elements with enhanced harvesting performance in a flexible printed circuit board. The implant is ultrasonically powered through a portable external dual-frequency transducer and generates programmable biphasic stimulus pulses in clinically relevant frequencies. Furthermore, we demonstrate ultrasound-driven implants for long-term biosafety therapy in deep brain stimulation through an epileptic rodent model. With biocompatibility and improved electrical performance, the lead-free materials and devices presented here could provide a promising platform for developing implantable ultrasonic electronics in the future.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation

Wang,

Zhang,

Xue

et al. 2024

Nat Commun

Self Cite

View full text Add to dashboard Cite

show abstract

“…The direct piezoelectric effect is observed in piezoelectric materials when they undergo deformation. When subjected to mechanical stress, these materials generate negative and positive charges distributed across two opposing surfaces [258] (Figure 10a). Ultrasonic waves exert acoustic pressure on piezoelectric materials, leading to the generation of strain.…”

Section: Ultrasound-mediated Light Powering and Deliverymentioning

confidence: 99%

Illuminating the Brain: Advances and Perspectives in Optoelectronics for Neural Activity Monitoring and Modulation

Xu,

Momin,

Ahmed

et al. 2023

Advanced Materials

View full text Add to dashboard Cite

Optogenetic modulation of brain neural activity that combines optical and electrical modes in a unitary neural system has recently gained robust momentum. Controlling illumination spatial coverage, designing light‐activated modulators, and developing wireless light delivery and data transmission are crucial for maximizing the use of optical neuromodulation. To this end, biocompatible electrodes with enhanced optoelectrical performance, device integration for multiplexed addressing, wireless transmission, and multimodal operation in soft systems have been developed. This review provides an outlook for uniformly illuminating large brain areas while spatiotemporally imaging the neural responses upon optoelectrical stimulation with little artifacts. Representative concepts and important breakthroughs, such as head‐mounted illumination, multiple implanted optical fibers, and micro‐light‐delivery devices, are discussed. Examples of techniques that incorporate electrophysiological monitoring and optoelectrical stimulation are presented. Challenges and perspectives are posed for further research efforts toward high‐density optoelectrical neural interface modulation, with the potential for nonpharmacological neurological disease treatments and wireless optoelectrical stimulation.

show abstract

“…Many review articles recently demonstrated the use of various conductive biopolymers to fabricate wearable bioelectronics. [51][52][53][54] Conductive biopolymers, combined with various carbon-based or non-carbon-based nanofillers, have been shown to enhance electrical conductivity and superior sensing ability and, therefore, used for conductive electrode fabrication. A reader should read the cited literature for more details about the role of conductive nanofillers.…”

Section: Introductionmentioning

confidence: 99%

3D Printable Hydrogel Bioelectronic Interfaces for Healthcare Monitoring and Disease Diagnosis: Materials, Design Strategies, and Applications

Dutta,

Ganguly,

Randhawa

et al. 2024

Adv Materials Technologies

View full text Add to dashboard Cite

In recent years, additive manufacturing tools, such as 3D printing, has gained enormous attention in biomedical engineering for developing ionotropic devices, flexible electronics, skin‐electronic interfaces, and wearable sensors with extremely high precision and sensing accuracy. Such printed bioelectronics are innovative and can be used as multi‐stimuli response platforms for human health monitoring and disease diagnosis. This review systematically discusses the past, present, and future of the various printable and stretchable soft bioelectronics for precision medicine. The potential of various naturally and chemically derived conductive biopolymer inks and their nanocomposites with tunable physico‐chemical properties is also highlighted, which is crucial for bioelectronics fabrication. Then, the design strategies of various printable sensors for human body sensing are summarized. In conclusion, the perspectives on the future advanced bioelectronics are described, which will be helpful, particularly in the field of nano/biomedicine. An in‐depth knowledge of materials design to functional aspects of printable bioelectronics is demonstrated, with an aim to accelerate the development of next‐generation wearables.

show abstract

Emerging ultrasonic bioelectronics for personalized healthcare

Cited by 30 publications

References 273 publications

Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation

Lead-free dual-frequency ultrasound implants for wireless, biphasic deep brain stimulation

Illuminating the Brain: Advances and Perspectives in Optoelectronics for Neural Activity Monitoring and Modulation

3D Printable Hydrogel Bioelectronic Interfaces for Healthcare Monitoring and Disease Diagnosis: Materials, Design Strategies, and Applications

Contact Info

Product

Resources

About