Emerging Vitamin D Receptor-Centered Patterns of Genetic Overlap across Some Autoimmune Diseases and Associated Cancers

Zhang, Yue

doi:10.4172/2157-7412.1000e123

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The Vitamin D receptor (VDR) is expressed in multiple cells and numerous RA and autophagy-related genes, including mTOR, are potential candidate targets of Vitamin D (Vit D) and VDR [11, 12]. It maintains “robustness” in unfavorable conditions and serves a “capacitor” in homeostasis in RA biology [13, 14]. Peroxisome proliferator-activated receptor- γ (PPAR- γ ) is a primary target of Vit D [15].…”

Section: Introductionmentioning

confidence: 99%

Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γFunctional Module of Autophagy in Rheumatoid Arthritis

Wang

Zhang

et al. 2019

PPAR Research

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Dysregulated autophagy leads to autoimmune diseases including rheumatoid arthritis (RA). Arsenic trioxide (ATO) is a single agent used for the treatment of acute promyelocytic leukemia and is highly promising for other malignancies but is also attractive for RA, although its relationship with autophagy remains to be further clarified and its application optimized. For the first time, we report a defective functional module of autophagy comprising the Vitamin D receptor (VDR), PPAR-γ, microtubule-associated protein 1 light-chain 3 (LC3), and p62 which appears in RA synovial fibroblasts. ATO alleviated RA symptoms by boosting effective autophagic flux through significantly downregulating p62, the inflammation and catabolism protein. Importantly, low-dose ATO synergizes with Vitamin D in RA treatment.

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Section: Introductionmentioning

confidence: 99%

Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γFunctional Module of Autophagy in Rheumatoid Arthritis

Wang

Zhang

et al. 2019

PPAR Research

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“…Auto immune response: It is expressed as a consequence autoimmune disease [11][12][13][14][15], where the beta cells of pancreas are slowly demolished by the body's own immune system which reduces insulin production. In the development of type 1 diabetes both the environmental and genetic predisposing factors are significant, but the exact correlation is still unknown.…”

Section: Type 1 Diabetesmentioning

confidence: 99%

A Modern Review of Diabetes Mellitus: An Annihilatory Metabolic Disorder

Deepthi¹,

Sowjanya²,

Lidiya³

et al. 2018

J In Silico In Vitro Pharmacol

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Diabetes mellitus is a disorder occurs due to metabolic problems is most frequent globally. The main indication of diabetes mellitus is a hyperglycemia in blood which is due to inappropriate pancreatic insulin secretion or low insulin-directed fostering of glucose by target cells. Diabetes mellitus can be assorted into several types but the two major types are type 1 and type 2. For type 1 diabetes patients Insulin renewal therapy is the backbone, for patient with type 2 diabetes there must be a control diet and lifestyle modification. In type 2 Insulin is vital when blood glucose are unable to control by nutritional therapy, physical activity and other medication. For the cure of type 2 DM oral hypoglycemic agents are preferred. In type 1 novel approaches like Islet transplantation and artificial pancreas were developed. By using the pathophysiology of type 2 DM there has been developing of novel medications like glucagon-like peptide 1 analogoues: Dipeptidyl peptidase-IV inhibitors, inhibitors of the sodium-glucose cotransporter 2. Due to some complications some drugs were removed from the market.

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“…Sulfonylureas function by binding to and inhibiting the pancreatic ATP-dependent potassium channel that is normally involved in glucose-mediated insulin secretion. The main side effects of sulfonylureas are weight gain and hypoglycaemia [28] , and risk is increased in people with mild to moderate renal impairment and severe hepatic impairment. (d)The Biguanides: Biguanide and its derivatives for the management of diabetes have been started since middle ages.…”

Section: Third Generation Sulfonylureasmentioning

confidence: 99%

Current Antidiabetic Drugs and Strategies for the Treatment of Type 2 Diabetes Mellitus

Joshi¹

2017

WJPR

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A constant increase in the features of metabolic syndrome leading to serious complications including neuropathy, retinopathy and nephropathy has resulted in worldwide epidemic of Type 2 diabetes mellitus or insulin resistance. Most of the available antidiabetic drugs were developed in the absence of defined molecular targets or a clear understanding of disease pathogenesis. Moreover, the available drugs suffer from one or the other side effects. Emerging knowledge of key physiologic mechanisms related to probable causes of hepatic and muscle insulin resistance on glucose metabolism has led to a number of new emerging molecular drug targets. Type 2 diabetes mellitus is a major contributor of deaths in India and worldwide, there is a urgent need to develop new drugs that will be helpful to diminish the overall diabetic load of world population. The present review provides the description of existing antidiabetic drugs and their respective molecular targets. There is a information regarding the antidiabetic targets that include receptors and enzymes that enhance glucose-stimulated insulin secretion, suppress hepatic glucose production, increase skeletal muscle glucose transport and utilization, increase insulin sensitivity and intracellular insulin signaling with reduction in circulating and intracellular lipids. It also emphasizes on the need for developing novel antidiabetic drugs having lower side effects and more efficacy.

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Emerging Vitamin D Receptor-Centered Patterns of Genetic Overlap across Some Autoimmune Diseases and Associated Cancers

Cited by 3 publications

References 18 publications

Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γFunctional Module of Autophagy in Rheumatoid Arthritis

Arsenic Trioxide in Synergy with Vitamin D Rescues the Defective VDR-PPAR-γFunctional Module of Autophagy in Rheumatoid Arthritis

A Modern Review of Diabetes Mellitus: An Annihilatory Metabolic Disorder

Current Antidiabetic Drugs and Strategies for the Treatment of Type 2 Diabetes Mellitus

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