2019
DOI: 10.3892/or.2019.7290
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Emetine exhibits anticancer activity in breast cancer cells as an antagonist of Wnt/β‑catenin signaling

Abstract: Emetine, an amoebicidal drug, exerts potent anticancer activity against various solid tumors, however, the underlying molecular mechanism remains unclear. In the present study, the effects of emetine were investigated on various proteins involved in the Wnt/β-catenin signaling pathway, which has been linked to various human cancers. It was revealed that emetine blocked Wnt/β-catenin signaling by targeting components of this pathway, including the low-density lipoprotein-receptor-related protein 6 (LRP6) and di… Show more

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Cited by 22 publications
(26 citation statements)
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“…We note that while the four candidate compounds have been shown to exert antiviral effects against certain virus infections [ 31 , 32 , 33 ], they may also display broad antitumor activity [ 34 , 35 , 36 , 37 ]. Homoharringtonine is the only drug currently approved by the US Food and Drug Administration for the treatment of chronic myeloid leukemia [ 38 ].…”
Section: Discussionmentioning
confidence: 99%
“…We note that while the four candidate compounds have been shown to exert antiviral effects against certain virus infections [ 31 , 32 , 33 ], they may also display broad antitumor activity [ 34 , 35 , 36 , 37 ]. Homoharringtonine is the only drug currently approved by the US Food and Drug Administration for the treatment of chronic myeloid leukemia [ 38 ].…”
Section: Discussionmentioning
confidence: 99%
“…[14] It is documented that emetine attenuated the Wnt/β-catenin signaling pathway, leading to induction of apoptosis and weakened the migration and invasion of breast cancer. [15] Additionally, emetine suppressed proliferation and the metastatic abilities of lung cancer through the modulation of extracellular signalregulated kinase (ERK) and p38 mitogen-activated protein kinases (MAPKs), as well as the expression of matrix metalloproteinases (MMPs). [16] Those publications imply that emetine may be a promising drug candidate to become repositioned for use in anticancer reagents.…”
Section: Introductionmentioning
confidence: 99%
“…Similar to the above-described results, protein synthesis inhibitors exert essential roles in reversing gefitinib resistance. In this class of drugs, three small molecule drugs have been screened, including Emetine, cephaeline and homoharringtonine, among which the antitumor effects of Emetine have been widely reported, the mechanisms are mostly related to inducing apoptosis and blocking the cell cycle 42 . Our in vitro verification results also show that emetine and cephaeline can significantly increase the sensitivity of drug-resistant cells to gefitinib, and the molecular mechanism may be related to the regulation of PI3 and S100A8.…”
Section: Discussionmentioning
confidence: 99%