Emetine-induced lactate dehydrogenase release, functional changes and electrocardiographic changes in the rat heart in vitro

Pan, Shanlin; Combs, Alan B.

doi:10.1016/0887-2333(95)00014-y

Cited by 3 publications

(1 citation statement)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For instance, there are reports linking abuse of ipecac to an increased risk of supraventricular arrhythmias [6]. Emetine, an important ingredient in ipecac syrup was found to cause card i o toxicity, prolongation of the P-R interval, inhibition of the ventricular complexes and ventricular fibrillation in an isolated rat heart [11]. Nevertheless, in Israel, buying ipecac is restricted to patients with medical prescriptions.…”

Section: Discussionmentioning

confidence: 98%

Normal atrial conduction in medically treated patients with bulimia nervosa

Nussinovitch

Kaminer

Gur

2012

International Journal of Psychiatry in Clinical Practice

View full text Add to dashboard Cite

BN patients who are medically monitored and treated, have normal P wave parameters and P wave dispersion, and therefore do not appear to have an increased risk for developing supraventricular arrhythmias. Future research should focus on evaluating the effect of acute ingestion of emetic drugs on resting ECG of BN patients, as well as using signal averaging techniques and prolonged ECG-Holter monitoring.

show abstract

Section: Discussionmentioning

confidence: 98%

Normal atrial conduction in medically treated patients with bulimia nervosa

Nussinovitch

Kaminer

Gur

2012

International Journal of Psychiatry in Clinical Practice

View full text Add to dashboard Cite

show abstract

The Ipecac Alkaloids and Related Bases

Fujii

Ohba

1998

The Alkaloids: Chemistry and Biology

View full text Add to dashboard Cite

Emetine Inhibits Glycolysis in Isolated, Perfused Rat Hearts

Pan

Combs

2003

View full text Add to dashboard Cite

This work was designed to test whether phosphofructokinase is a target for emetine action on the heart. The effects of 37 microM emetine on the activities of phosphofructokinase and hexokinase were measured in homogenates from perfused hearts. The action of increasing concentrations of emetine was determined in nonperfused heart homogenates. The effect of 37 microM emetine or control solutions on the concentration of fructose-6-phosphate and fructose- 1,6-phosphate was measured. The effect of 37 microM emetine or control perfusion on the utilization of fructose-6-phosphate by phosphofructokinase in centrifugation supernatants of homogenates and in reconstituted 27,000g pellets was measured. Double-reciprocal plots of fructose-6-phosphate concentrations vs phosphofructokinase activities were plotted. Emetine decreased phosphofructokinase activity in homogenates from both perfused and nonperfused hearts. Emetine did not inhibit cardiac hexokinase activity. In homogenates from nonperfused hearts, the maximal inhibition with high concentrations of emetine was approx 50%. Emetine perfusion caused a simultaneous increase in the phosphofructokinase substrate fructose-6-phosphate and a decrease in the phosphofructokinase product fructose-1,6-bisphosphate. Phosphofructokinase and, consequently, glycolytic flux appear to be subcellular targets for emetine in the heart. Homogenate centrifugation studies indicate that emetine acts on bound rather than unbound phosphofructokinase. The inhibition may be uncompetitive in nature.

show abstract

Emetine-induced lactate dehydrogenase release, functional changes and electrocardiographic changes in the rat heart in vitro

Cited by 3 publications

References 29 publications

Normal atrial conduction in medically treated patients with bulimia nervosa

Normal atrial conduction in medically treated patients with bulimia nervosa

The Ipecac Alkaloids and Related Bases

Emetine Inhibits Glycolysis in Isolated, Perfused Rat Hearts

Contact Info

Product

Resources

About