EMF effects on microcirculatory system

Ohkubo, Chiyoji; Okano, Hideyuki; Ushiyama, Akira; Masuda, Hiroshi

doi:10.1007/s10669-007-9082-z

Cited by 12 publications

(11 citation statements)

References 54 publications

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“…Many previous studies have proven that the effective range of most of the SMF exposures producing positive impacts on the organism was mainly concentrated at moderate field strengths with milli Tesla (mT) levels [Saunders, 2005;Ohkubo et al, 2007]. The effectiveness of this field strength covered a range of extensive investigation areas such as the cardiovascular system, nervous system, musculoskeletal system, and cancer.…”

Section: Discussionmentioning

confidence: 99%

“…During the past decades, there has been substantial and growing evidence that static magnetic fields (SMF) and pulsed electromagnetic fields (PEMF) as alternative noninvasive methods can both produce satisfying therapeutic effects on various disorders [Aaron et al, 2004;Saunders, 2005;Markov, 2007;Ohkubo et al, 2007]. Numerous animal experiments have demonstrated that SMF could help promote the healing of various tissue defects, such as fresh and nonunion fracture, skin wound and ulcer, nerve injury, etc.…”

Section: Introductionmentioning

confidence: 99%

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Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Jing

Shen

Cai

et al. 2010

Bioelectromagnetics

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Diabetic wound (DW) problems are becoming a formidable clinical challenge due to the sharp increase in the diabetic population and the high incidence of DW. Static magnetic field (SMF) therapy, an inexpensive and accessible noninvasive method, has been proven to be effective on various tissue repairs. However, the issue of the therapeutic effect of SMF on DW healing has never been investigated. The objective of this study was to systematically evaluate the effect of a 180 mT moderate-intensity gradient SMF on DW healing in streptozotocin-induced diabetic rats. Forty-eight 3-month-old male Sprague-Dawley rats (32 diabetic and 16 non-diabetic rats) were assigned to three equal groups: normal wound, DW, and DW + SMF groups. An open circular wound with 1.5 cm diameter was created in the dorsum. The wound was covered with a dressing and the magnet was fixed on top of the dressing. On days 5, 12, and 19, four rats of each group were euthanized and gross wound area, histology and tensile strength were evaluated. The wound area determination suggested that SMF significantly increased the healing rate and reduced the gross healing time. This result was further confirmed by histological observations. The wound tensile strength, reflecting the amount and quality of collagen deposition, increased to a larger extent in the DW + SMF group on days 12 and 19 compared with the DW group. The results indicated that 180 mT SMF presented a beneficial effect on DW healing, and implied the clinical potential of SMF therapy in accelerating DW repair and releasing the psychological and physical burdens of diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Jing

Shen

Cai

et al. 2010

Bioelectromagnetics

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“…Several attempts have been made to explore the parameters of microcirculation and microvasculature when tissue and/or blood vessels have been exposed to moderate intensity SMF. These studies have been well reviewed by Ohkubo et al (2007), McKay et al (2007, and McNamee et al (2009). For example, the rabbit ear chamber (REC) offers the advantages of long-term monitoring the target site with superior optical quality (Asano et al 1965).…”

Section: Moderate Intensity Static Magnetic Fields (Smf)mentioning

confidence: 99%

“…Its therapeutic potential (Ratterman et al 2002;Ohkubo et al 2007;Markov 2007aMarkov , b, 2009Markov , 2010Henry et al 2008;Colbert et al 2008Colbert et al , 2009) and possible health effects (ICNIRP 2009) have been reviewed. In this review, we introduce and focus on recent studies, including our own, describing the moderate intensity SMF effects on the circulatory system.…”

Section: Introductionmentioning

confidence: 99%

Clinical aspects of static magnetic field effects on circulatory system

Ohkubo

Okano

2010

Environmentalist

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Increased knowledge of the magnetic field influence on hemodynamic function may have significant therapeutic potential and possible health effects. For example, magnetic field therapy using moderate intensity static magnetic fields (SMF) in the mT range (in particular, 1-600 mT) could be useful for circulatory diseases, including ischemic pain, inflammation, and hypertension, primarily due to the modulation of blood flow and/or blood pressure through the nervous system. We suggested that the mechanisms of SMF effects on the circulatory system in the mT range could be mediated by suppressing or enhancing the action of biochemical effectors, thereby inducing homeostatic effects biphasically. The potent mechanisms of SMF effects have often been linked to nitric oxide pathway, Ca 2? -dependent pathway, sympathetic nervous system (e.g., BRS and the action of sympathetic agonists or antagonists), and neurohumoral regulatory system (e.g., production and secretion of angiotensin II and aldosterone). Thus, this review mainly focuses on the experimental studies of SMF effects on the circulatory system in animals and may provide the physiological basis for future clinical investigations of SMF therapy.

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“…Particular attention was given to the potential of magnetism on the microcirculatory system. Many experiments had been done on both human and animals to understand the mechanism of the interaction between MF and microcirculation [9,10]. Also, some studies on the cellular level had been done to explore the cellular activities under the effect of MF [11].…”

Section: Introductionmentioning

confidence: 99%

Direct monitoring of erythrocytes aggregation under the effect of the low-intensity magnetic field by measuring light transmission at wavelength 800 nm

Elblbesy

2017

Polish Journal of Medical Physics and Engineering

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Interacting electromagnetic field with the living organisms and cells became of the great interest in the last decade. Erythrocytes are the most common types of the blood cells and have unique rheological, electrical, and magnetic properties. Aggregation is one of the important characteristics of the erythrocytes which has a great impact in some clinical cases. The present study introduces a simple method to monitor the effect of static magnetic field on erythrocytes aggregation using light transmission. Features were extracted from the time course curve of the light transmission through the whole blood under different intensities of the magnetic field. The findings of this research showed that static magnetic field could influence the size and the rate of erythrocytes aggregation. The strong correlations confirmed these results between the static magnetic field intensity and both the time of aggregation and sedimentation of erythrocytes. From this study, it can be concluded that static magnetic field can be used to modify the mechanisms of erythrocytes aggregation.

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EMF effects on microcirculatory system

Cited by 12 publications

References 54 publications

Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Effects of 180 mT static magnetic fields on diabetic wound healing in rats

Clinical aspects of static magnetic field effects on circulatory system

Direct monitoring of erythrocytes aggregation under the effect of the low-intensity magnetic field by measuring light transmission at wavelength 800 nm

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