Electromyography (EMG) signals are biomedical signals that measure electrical currents generated during muscle contraction. These signals are strongly influenced by physiological and anatomical characteristics of the muscles and represent the neuromuscular activities of the human body. The evolution of EMG analysis and acquisition techniques makes this technology more reliable for production engineering applications, overcoming some of its inherent issues. Taking as an example, the fatigue monitoring of workers as well as enriched human–machine interaction (HMI) systems used in collaborative tasks are now possible with this technology. The main objective of this research is to evaluate the current implementation of EMG technology within production engineering, its weaknesses, opportunities, and synergies with other technologies, with the aim of developing more natural and efficient HMI systems that could improve the safety and productivity within production environments.