“…Regarding ibuprofen, six out of the seven studies included in a 2020 review found an association between administration of ibuprofen and an increased risk of complications in children with lower respiratory tract infection. 4 Antipyretic therapy is administered to improve patient comfort; however, controlled studies have never quantified the degree of comfort that antipyretics provide patients, and a Cochrane review on treating fever in children concluded that there is insufficient evidence that antipyretics have a superior effect than placebo. In contrast, trials conducted more than 40 years ago showed that reducing fever may lead to significantly higher rates of viral shedding.…”