Emil Selenka on the embryonic membranes of the mouse and placentation in gibbons and orangutans

Carter, A.M.; Pijnenborg, Robert

doi:10.1016/j.placenta.2015.11.005

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…In great apes (human, chimpanzee, gorilla and orangutan) and lesser apes (gibbon) 56 , embryos undergo interstitial implantation, as the late blastocyst penetrates through the epithelial lining of the endometrium and invades into the underlying connective tissue. Embryos of other primate species, including Old World (rhesus and cynomolgus) and New World monkeys (marmoset), implant superficially, with the blastocyst expanding in the central cavity of the uterus 57 .…”

Section: Development Of the Yolk Sacmentioning

confidence: 99%

Origin and function of the yolk sac in primate embryogenesis

2020

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Human embryogenesis is hallmarked by two phases of yolk sac development. The primate hypoblast gives rise to a transient primary yolk sac, which is rapidly superseded by a secondary yolk sac during gastrulation. Moreover, primate embryos form extraembryonic mesoderm prior to gastrulation, in contrast to mouse. The function of the primary yolk sac and the origin of extraembryonic mesoderm remain unclear. Here, we hypothesise that the hypoblast-derived primary yolk sac serves as a source for early extraembryonic mesoderm, which is supplemented with mesoderm from the gastrulating embryo. We discuss the intricate relationship between the yolk sac and the primate embryo and highlight the pivotal role of the yolk sac as a multifunctional hub for haematopoiesis, germ cell development and nutritional supply.

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Section: Development Of the Yolk Sacmentioning

confidence: 99%

Origin and function of the yolk sac in primate embryogenesis

2020

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“…Thus a more extensive invasion of tissue and blood vessels is characteristic of humans and great apes, the species that have MHC-C. Humans (161), chimpanzees (162,163), and gorillas (164) exhibit the most extensive invasion (165), which is influenced by the KIR genotype of the mother and the MHC-C genotypes of both parents. Uterine invasion has yet to be studied in the orangutan (165).…”

Section: Kir2dl1mentioning

confidence: 99%

“…Humans (161), chimpanzees (162,163), and gorillas (164) exhibit the most extensive invasion (165), which is influenced by the KIR genotype of the mother and the MHC-C genotypes of both parents. Uterine invasion has yet to be studied in the orangutan (165). However, given that MHC-C is limited to the C1 epitope and to 50% of MHC haplotypes, the prediction is that uterine invasion in orangutan pregnancy is generally less than in human or chimpanzee pregnancy.…”

Section: Kir2dl1mentioning

confidence: 99%

Genetics of Natural Killer Cells in Human Health, Disease, and Survival

Parham

Guethlein²

2018

Annu. Rev. Immunol.

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Natural killer (NK) cells have vital functions in human immunity and reproduction. In the innate and adaptive immune responses to infection, particularly by viruses, NK cells respond by secreting inflammatory cytokines and killing infected cells. In reproduction, NK cells are critical for genesis of the placenta, the organ that controls the supply of oxygen and nutrients to the growing fetus. Controlling NK cell functions are interactions of HLA class I with inhibitory NK cell receptors. First evolved was the conserved interaction of HLA-E with CD94:NKG2A; later established were diverse interactions of HLA-A, -B, and -C with killer cell immunoglobulin-like receptors. Characterizing the latter interactions is rapid evolution, which distinguishes human populations and all species of higher primate. Driving this evolution are the different and competing selections imposed by pathogens on NK cell-mediated immunity and by the constraints of human reproduction on NK cell-mediated placentation. Promoting rapid evolution is independent segregation of polymorphic receptors and ligands throughout human populations.

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“…Outside of the labyrinth, trophoblast giant cells (TGCs) are in direct contact with the maternal decidua. Lastly, spongiotrophoblast (SpT) and glycogen cells (GC) form the major endocrine compartment of the placenta [ 17 , 18 ]. Together, these trophoblast subtypes perform the central functions of the mouse placenta, which are to provide oxygen and nutrients to the fetus, while removing carbon dioxide and other waste products, to metabolize substances and hormones, and to protect the fetus against infections and xenobiotics.…”

Section: Foundations Of Placental Development: a Brief Overview Of Tissues Cells Molecules And Epigeneticsmentioning

confidence: 99%

Cellular Complexity of Hemochorial Placenta: Stem Cell Populations, Insights from scRNA-seq, and SARS-CoV-2 Susceptibility

et al. 2021

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Purpose of Review The placenta is a transient organ that forms de novo and serves a critical role in supporting fetal growth and development. Placental oxygen, nutrients, and waste are transported through processes that depend on vascular structure and cell type-specific expression and localization of membrane transporters. Understanding how the placenta develops holds great significance for maternal–fetal medicine. The purpose of this review is to examine current information regarding placental progenitor populations. Recent Findings Recent advancements in single-cell RNA sequencing (scRNA-seq) provide unprecedented depth for the investigation of cell type-specific gene expression patterns in the placenta. Thus far, several mouse placenta scRNA-seq studies have been conducted which produced and analyzed transcriptomes of placental progenitors and cells of the fully developed placenta between embryonic day (E) 7.0 and E12.5. Together with human placenta scRNA-seq data which, in part, has been produced through coordinated research campaigns in the scientific community to understand the potential for SARS-CoV-2 infection, these mammalian studies lend fundamental insight into the cellular and molecular composition of hemochorial placentae found in both mouse and human. Summary Single-cell placenta research has advanced understanding of tissue-resident stem cells and molecules that are poised to support maternal–fetal communication and nutrient transport. Herein, we provide context for these recent findings by reviewing placental anatomy and cell populations, and discuss recent scRNA-seq mouse placenta findings. Further research is needed to evaluate the utility of placental stem cells in the development of new therapeutic approaches for the treatment of wound healing and disease.

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Emil Selenka on the embryonic membranes of the mouse and placentation in gibbons and orangutans

Cited by 9 publications

References 21 publications

Origin and function of the yolk sac in primate embryogenesis

Origin and function of the yolk sac in primate embryogenesis

Genetics of Natural Killer Cells in Human Health, Disease, and Survival

Cellular Complexity of Hemochorial Placenta: Stem Cell Populations, Insights from scRNA-seq, and SARS-CoV-2 Susceptibility

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