We present results for the electron-impact excitation of all Ne-like ions from Na + to Kr 26+ obtained using the intermediate-coupling frame transformation R-matrix approach. For each ion's calculation, the close-coupling expansion is taken to be the 113 LS terms (209 levels) belonging to the configurations [1s 2 ]2s 2 2p 6 , 2s 2 2p 5 {3, 4, 5}l, 2s2p 6 {3, 4, 5}l (l ∈ s, p, d, f, and g), and 2s 2 2p 5 {6, 7}l (l ∈ s, p, and d). An additional configuration interaction effect arising from configurations of 2s 2 2p 4 3l{3, 4, 5}l (l ∈ s, p, d, f and g) was included in the target expansion. A detailed comparison of the target structure has been made for six specific ions (Si 4+ , Ar 8+ , Ca 10+ , Fe 16+ , Ni 18+ , and Kr 26+ ) spanning the sequence to assess the accuracy for the entire sequence. Effective collision strengths (Υs) are presented at temperatures ranging from 2×10 2 (q+1) 2 K to 2×10 6 (q+1) 2 K (where q is the residual charge of ions, i.e. Z −10). Detailed comparisons for the Υs are made with the results of previous calculations for several ions, which span the sequence. Furthermore, we examine the iso-electronic trends of effective collision strengths as a function of temperature. The present results are the only R-matrix ones for the majority of the ions and the most extensive and complete data for modelling to-date.