Emodin-Containing MCM-41 Type Mesoporous Silica Nanoparticle Drug Delivery System

Santos, Isabella Menezes dos; Pereira, S. P.; Mezacasa, A.V.; Cáceres, Osmar Ignacio Ayala; Timóteo, Fernanda; Lopes, André Sereno; Pino, K. F. del; Duarte, Adriana Pereira; Cardoso, Teófilo Fernando Mazon; Castro, Gustavo Rocha de; Rashid, Haroon; Martines, Marco Antônio Utrera

doi:10.1007/s11237-020-09649-z

Cited by 3 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First reported to be synthesized by scientists from Mobil Corporation in 1992, MCM-41 is a mesoporous molecular sieve material with a large pore volume and a uniformly distributed pore size that is adjustable within a certain range. It is widely used in the adsorption of harmful substances in the environmental field and the study of catalysts [ 24 , 25 , 26 ]. In 2001, in the drug research field, Vallet et al [ 27 ] first used MCM-41 as an adsorbent to adsorb ibuprofen molecules for drug molecule delivery.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of New Electrospun Poly(lactic acid) Nanofiber Antioxidative Active Packaging Films Containing MCM-41 Mesoporous Molecular Sieve Loaded with Phloridzin and Their Application in Strawberry Packaging

Xie

Cheng

et al. 2022

Nanomaterials

View full text Add to dashboard Cite

Health concerns about food safety have increased in recent years. In order to ensure the safety and increase the shelf-life of food, many methods have been used to slow down the oxidation rate of food fat. In order to solve this problem, a new type of antioxidant-active packaging has emerged. Poly(lactic acid) (PLA) films containing phloridzin adsorbed on to an MCM-41 mesoporous molecular sieve were prepared by electrostatic spinning, using PLA as a film-forming substrate, phloridzin as an antioxidant, and MCM-41 as the adsorption and controlled release carrier. The physical properties of the new films—including microscopic structure, water vapor transmission rate, and fresh-keeping effects, as well as the mechanical, thermal, antioxidant, and antibacterial properties—were studied. When the mass ratio of MCM-41 to phloridzin is 1:2, the nanofiber membrane achieves a 53.61% free-radical scavenging rate and better antibacterial performance (85.22%) due to the high content of phloridzin (30.54%). Additionally, when the mass ratio of the molecular sieve to phloridzin is 1:2 and 3:4 (with the best antibacterial performance of 89.30%), the films significantly delay lipid oxidation in the strawberry packaging, allowing the fresh-keeping time to be extended to up to 21 days before mildew appears. In this study, an MCM-41 mesoporous molecular sieve was used to load phloridzin for the first time. The packaging film with phloridzin, MCM-41, and poly(lactic acid) were used as the raw materials and electrospinning technology was used to prepare the packaging film with antioxidant activity. The packaging film was used for the first time in the packaging of strawberries.

show abstract

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of New Electrospun Poly(lactic acid) Nanofiber Antioxidative Active Packaging Films Containing MCM-41 Mesoporous Molecular Sieve Loaded with Phloridzin and Their Application in Strawberry Packaging

Xie

Cheng

et al. 2022

Nanomaterials

View full text Add to dashboard Cite

show abstract

Mesoporous molecular sieve-based materials for catalytic oxidation of VOC: A review

Tang

Jiang

et al. 2023

Journal of Environmental Sciences

View full text Add to dashboard Cite

Synthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles

Karnopp,

Jorge,

da Silva

et al. 2024

Pharmaceutics

View full text Add to dashboard Cite

This study describes the synthesis and characterization of chlorambucil (CLB)-functionalized mesoporous silica nanoparticles (MSNs) for potential application in cancer therapy. The nanoparticles were designed with a diameter between 20 and 50 nm to optimize cellular uptake and avoid rapid clearance from the bloodstream. The synthesis method involved modifying a previously reported technique to reduce particle size. Successful functionalization with CLB was confirmed through various techniques, including Fourier transform infrared spectroscopy (FTIR) and elemental analysis. The cytotoxicity of the CLB-functionalized nanoparticles (MSN@NH2-CLB) was evaluated against human lung adenocarcinoma cells (A549) and colon carcinoma cells (CT26WT). The results suggest significantly higher cytotoxicity of MSN@NH2-CLB compared to unbound CLB, with improved selectivity towards cancer cells over normal cells. This suggests that MSN@NH2-CLB holds promise as a drug delivery system for targeted cancer therapy.

show abstract

Emodin-Containing MCM-41 Type Mesoporous Silica Nanoparticle Drug Delivery System

Cited by 3 publications

References 28 publications

Preparation and Characterization of New Electrospun Poly(lactic acid) Nanofiber Antioxidative Active Packaging Films Containing MCM-41 Mesoporous Molecular Sieve Loaded with Phloridzin and Their Application in Strawberry Packaging

Preparation and Characterization of New Electrospun Poly(lactic acid) Nanofiber Antioxidative Active Packaging Films Containing MCM-41 Mesoporous Molecular Sieve Loaded with Phloridzin and Their Application in Strawberry Packaging

Mesoporous molecular sieve-based materials for catalytic oxidation of VOC: A review

Synthesis, Characterization, and Cytotoxicity Evaluation of Chlorambucil-Functionalized Mesoporous Silica Nanoparticles

Contact Info

Product

Resources

About