Emodin-Loaded PLGA-TPGS Nanoparticles Combined with Heparin Sodium-Loaded PLGA-TPGS Nanoparticles to Enhance Chemotherapeutic Efficacy Against Liver Cancer

Liu, Hongyan; Xu, Hong; Zhang, Chenghong; Gao, Meng; Gao, Xiaoguang; Ma, Chuchu; Lv, Li; Gao, Dongyan; Deng, Sa; Wang, Changyuan; Tian, Ye

doi:10.1007/s11095-016-2010-5

Cited by 15 publications

(10 citation statements)

References 32 publications

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“…There were some reports indicating that rhubarb extracts induced apoptosis or inhibit migration of cancer cells ( 9 , 10 ). For example, emodin extracted from rhubarb root has anti-cancer effects in numerous cancers such as prostate, breast and cervical cancers ( 11 – 15 ). Chrysophanol was also reported for its anti-cancer role, showing that it inhibits viability of colon cancer cells through inhibition of the NF-κB-mediated signaling cascades ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines

Ren

Dai

et al. 2018

Mol Med Report

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Chrysophanol is an anthraquinone compound, which exhibits anticancer effects on certain types of cancer cells. However, the effects of chrysophanol on human breast cancer remain to be elucidated. The aim of the present study was to clarify the role of chrysophanol on breast cancer cell lines MCF-7 and MDA-MB-231, and to identify the signal transduction pathways regulated by chrysophanol. MTT assay and flow cytometric analysis demonstrated that chrysophanol inhibited cell proliferation, and cell cycle progression in a dose-dependent manner. The expression of cell cycle-associated cyclin D1 and cyclin E were downregulated while p27 expression was upregulated following chrysophanol treatment at the mRNA, and protein levels. The Annexin V/propidium iodide staining assay results revealed that apoptosis levels increased following chrysophanol treatment. Chrysophanol upregulated caspase 3 and poly (ADP-ribose) polymerase cleavage in both cell lines. Furthermore, chrysophanol enhanced the effect of paclitaxel on breast cancer cell apoptosis. In addition, chrysophanol downregulated apoptosis regulator Bcl-2 protein, and transcription factor p65 and IκB phosphorylation. Inhbition of nuclear factor (NF)-κB by ammonium pyrrolidine dithiocarbamate diminished the effect of chrysophanol on apoptosis and associated proteins. In conclusion, the results of the current study demonstrated that chrysophanol effectively suppresses breast cancer cell proliferation and facilitates chemosentivity through modulation of the NF-κB signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines

Ren

Dai

et al. 2018

Mol Med Report

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“…Recently, several studies have shown that emodin can inhibit tumour growth by inhibiting tumour cell proliferation and inducing apoptosis (14)(15)(16). Emodin can also synergize with various antitumour drugs to reduce tumour resistance (17). Aloe-emodin, reported as a potential anticancer agent, has a molecular structure similar to that of emodin.…”

Section: Discussionmentioning

confidence: 99%

Emodin inhibits the proliferation and migration of B16F10 cells and induces their apoptosis

Yuan¹,

Chen²,

Wang³

et al. 2020

Transl Cancer Res TCR

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Background: Emodin, extracted from the rhizomes of various Chinese herbs, is a natural anthraquinone derivative with the formula C15H10O5. Many recent studies have shown that emodin has an antitumour effect. In this study, emodin was investigated in vitro to observe its effect on the proliferation, migration, and apoptosis of the B16F10 melanoma cell line.Methods: B16F10 cells were treated with 20, 40, 60, or 80 μM emodin for 24 h. A Cell Counting Kit-8 (CCK-8) was used to measure the effect of emodin on cell proliferation. After 24 h of emodin treatment, a scratch test was used to detect the wound healing rate of each group. A Transwell test was used to measure the effect of emodin on cell migration ability. The apoptosis rate of the B16F10 cells was determined by a TUNEL assay. The expression of caspase-3 was measured by western blot analysis.Results: Compared with the control group, emodin significantly inhibited the proliferation and migration of the B16F10 cells in a concentration-dependent manner. Emodin also inhibited the migration of the B16F10 cells and induced their apoptosis.Conclusions: Emodin can effectively suppress the viability and migration of B16F10 cells and may induce apoptosis through the mitochondrial pathway or death receptor-mediated pathway.

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“… Liu et al, 2016a combined heparin and emodin with a nano-molecular carrier polylactic-co-glycolic acid-D- α -tocopheryl polyethylene glycol 1,000 succinate (PLGA-TPGS) to form heparin-loaded PLGA-TPGS nanoparticles and emodin-loaded PLGA-TPGS nanoparticles, respectively. Moreover, the researchers found that the two synergistically promote apoptosis in vivo and in vitro , and inhibit tumor growth in vivo ( Liu et al, 2016a ; Liu et al, 2016b ). Dong et al distributed emodin in a new type of biomaterial N-acetylaminogalactosyl-poly (lactide-co-glycolide)-succinyl-D-a-tocopherol polyethylene glycol 1,000 succinate (GalNAc-PLGA-sTPGS) to form a new type of nanoparticle, EGTPN, and found that EGTPN in vitro induced HepG2 apoptosis more effectively than emodin alone (H. Dong et al, 2018 ).…”

Section: Active Ingredients Of Rhei Radix Et Rhizoma Used For Hcc Tre...mentioning

confidence: 99%

Induction of Apoptosis by Metabolites of Rhei Radix et Rhizoma (Da Huang): A Review of the Potential Mechanism in Hepatocellular Carcinoma

et al. 2022

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Liver cancer is a global disease with a high mortality rate and limited treatment options. Alternations in apoptosis of tumor cells and immune cells have become an important method for detailing the underlying mechanisms of hepatocellular carcinoma (HCC). Bcl-2 family, Caspase family, Fas and other apoptosis-related proteins have also become antagonistic targets of HCC. Da Huang (Rhei Radix et Rhizoma, RR), a traditional Chinese herb, has recently demonstrated antitumor behaviors. Multiple active metabolites of RR, including emodin, rhein, physcion, aloe-emodin, gallic acid, and resveratrol, can successfully induce apoptosis and inhibit HCC. However, the underlying mechanisms of these metabolites inhibiting the occurrence and development of HCC by inducing apoptosis is complicated owing to the multi-target and multi-pathway characteristics of traditional Chinese herbs. Accordingly, this article reviews the pathways of apoptosis, the relationship between HCC and apoptosis, the role and mechanism of apoptosis induced by mitochondrial endoplasmic reticulum pathway and death receptor pathway in HCC and the mechanism of six RR metabolites inhibiting HCC by inducing apoptosis.

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Emodin-Loaded PLGA-TPGS Nanoparticles Combined with Heparin Sodium-Loaded PLGA-TPGS Nanoparticles to Enhance Chemotherapeutic Efficacy Against Liver Cancer

Abstract: The research suggests that the combination therapy system of EPTNs and HPTNs could be a new direction for liver cancer therapy.

Cited by 15 publications

References 32 publications

Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines

Chrysophanol inhibits proliferation and induces apoptosis through NF-κB/cyclin D1 and NF-κB/Bcl-2 signaling cascade in breast cancer cell lines

Emodin inhibits the proliferation and migration of B16F10 cells and induces their apoptosis

Induction of Apoptosis by Metabolites of Rhei Radix et Rhizoma (Da Huang): A Review of the Potential Mechanism in Hepatocellular Carcinoma

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