Emodin protects knee joint cartilage in rats through anti-matrix degradation pathway: An in vitro and in vivo study

Hu, Hailong; Song, Xiaopeng; Li, Yue; Ma, Tianwen; Bai, Hui; Zhao, Mingchao; Wang, Xinyu; Liu, Lin; Li, Gao

doi:10.1016/j.lfs.2020.119001

Cited by 20 publications

(14 citation statements)

References 42 publications

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“…H&E staining makes the nucleus blue and the components of the cytoplasm and ECM red, mainly to observe the tissue morphology and identify the cells. 25 Fig. 3 shows that there was no significant difference between the normal group and the sham group, in which the surface of the cartilage was smooth and the structure was complete.…”

Section: Resultsmentioning

confidence: 90%

Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways

Wang

et al. 2022

Food Funct.

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Section: Resultsmentioning

confidence: 90%

Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways

Wang

et al. 2022

Food Funct.

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“…Hu et al [94] in their in vitro and in vivo studies confirmed the protective effect of emodin in the treatment of osteoarthritis. Tissue expression of MMP-12, ADAMTS-4 (a disintegrin and metalloproteinase with thrombospondin motifs 4) and iNOS decreased after the treatment with emodin, as well as COX-2 and PGE2 levels in blood.…”

Section: Arthritismentioning

confidence: 86%

The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update

Stompor-Gorący

2021

IJMS

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Emodin (6-methyl-1,3,8-trihydroxyanthraquinone) is a naturally occurring anthraquinone derivative found in roots and leaves of various plants, fungi and lichens. For a long time it has been used in traditional Chinese medicine as an active ingredient in herbs. Among other sources, it is isolated from the rhubarb Rheum palmatum or tuber fleece-flower Polygonam multiflorum. Emodin has a wide range of biological activities, including diuretic, antibacterial, antiulcer, anti-inflammatory, anticancer and antinociceptive. According to the most recent studies, emodin acts as an antimalarial and antiallergic agent, and can also reverse resistance to chemotherapy. In the present work the potential therapeutic role of emodin in treatment of inflammatory diseases, cancers and microbial infections is analysed.

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“…The control group was injected with sterile saline. A suitable concentration of emodin was established based on a previous study [17]. After 6 weeks of administration of emodin, blood samples were collected from the rats through the tail vein.…”

Section: Rat Model Of Posttraumatic Oa and Emodin Treatmentmentioning

confidence: 99%

“…Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone derivative and an active ingredient of Chinese herbs, including Polygonum cuspidatum, Rheum palmatum, Aloe vera, Polygonum multiflorum, and Cassia obtusifolia [15]. Emodin is also a potential protective agent for OA [16,17], but its pharmacological mechanisms of action require a more detailed study. Emodin can promote the elimination of oxidation products in cells.…”

Section: Introductionmentioning

confidence: 99%

Emodin Attenuates the ECM Degradation and Oxidative Stress of Chondrocytes through the Nrf2/NQO1/HO‐1 Pathway to Ameliorate Rat Osteoarthritis

et al. 2022

Oxidative Medicine and Cellular Longevity

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Osteoarthritis (OA) substantially reduces the quality of life of the elderly. OA therapy remains a challenge since no treatment options for its causes are so far available. Over recent years, researchers have speculated that emodin may represent a potential treatment strategy for OA. However, it remains unclear whether the mechanism of action of emodin is associated with the inhibition of OA-induced oxidative stress. In the present study, the potential antioxidant mechanism of action of emodin and its protective properties against the development of OA were investigated both in vitro and in vivo. In vitro, emodin inhibited the production of reactive oxygen species (ROS) in chondrocytes induced by hydrogen peroxide (H2O2) and reduced the expression of matrix metalloproteinase (MMP)3 and MMP13 in a concentration-dependent manner. It was found that emodin upregulated the Nrf2/NQO1/HO-1 pathway, thereby attenuating the effects of oxidative stress caused by OA. In a rat model of posttraumatic OA induced by anterior cruciate ligament transection (ACLT), emodin reduced the extent of joint swelling. Emodin attenuated oxidative damage in the cartilage by upregulating superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH) activity, reducing malondialdehyde (MDA) concentration and inhibiting the expression of the extracellular matrix (ECM) degradation biomarkers cartilage oligomeric matrix protein (COMP), and C-terminal telopeptide of type I collagen (CTX-I) and type II collagen (CTX-II), thereby reducing cartilage damage. In summary, the present study indicates that emodin reduces ECM degradation and oxidative stress in chondrocytes via the Nrf2/NQO1/HO-1 pathway, thereby ameliorating OA in rats.

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Emodin protects knee joint cartilage in rats through anti-matrix degradation pathway: An in vitro and in vivo study

Cited by 20 publications

References 42 publications

Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways

Effects of type II collagen hydrolysates on osteoarthritis through the NF-κB, Wnt/β-catenin and MAPK pathways

The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update

Emodin Attenuates the ECM Degradation and Oxidative Stress of Chondrocytes through the Nrf2/NQO1/HO‐1 Pathway to Ameliorate Rat Osteoarthritis

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