Emotion deficits in schizophrenia: Timing matters.

Kring, Ann M.; Gard, Marja Germans; Gard, David E.

doi:10.1037/a0021402

Cited by 66 publications

(50 citation statements)

References 58 publications

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“…Inappropriate value representation in people with schizophrenia may also compromise their motivation to approach or avoid leading to suboptimal decision-making (Germans and Kring, 2000;Gold et al, 2012;Gold et al, 2008). Finally, the maintenance and recall of emotional experience which are impaired in people with schizophrenia are essential for anticipatory pleasure encoding (Kring et al, 2011;Strauss and Gold, 2012). However, to establish a causal relationship between the dampened anticipatory pleasure and the abovementioned factors in schizophrenia-spectrum disorders requires further research.…”

Section: Deficits In Anticipatory Pleasurementioning

confidence: 92%

Experiential pleasure deficits in different stages of schizophrenia

Zhi

Lui

Geng

et al. 2015

Schizophrenia Research

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Section: Deficits In Anticipatory Pleasurementioning

confidence: 92%

Experiential pleasure deficits in different stages of schizophrenia

Zhi

Lui

Geng

et al. 2015

Schizophrenia Research

Self Cite

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“…Further, individuals with schizophrenia show intact responses in emotion-modulated startle paradigms during the presentation of pleasant stimuli, when given sufficient time to process the stimuli (Schlenker et al 1995;Curtis et al 1999;Volz et al 2003;Kring et al 2011) and intact memory enhancement for positive stimuli (Mathews and Barch 2004;Horan et al 2006;Hall et al 2007) though see (Herbener et al 2007). …”

Section: Schizophreniamentioning

confidence: 95%

Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia

Deanna¹,

Pagliaccio²,

Luking³

2015

Current Topics in Behavioral Neurosciences

191

151

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Motivational and hedonic impairments are core aspects of a variety of types of psychopathology. These impairments cut across diagnostic categories and may be critical to understanding major aspects of the functional impairments accompanying psychopathology. Given the centrality of motivational and hedonic systems to psychopathology, the Research Domain Criteria (RDoC) initiative includes a "positive valence" systems domain that outlines a number of constructs that may be key to understanding the nature and mechanisms of motivational and hedonic impairments in psychopathology. These component constructs include initial responsiveness to reward, reward anticipation or expectancy, incentive or reinforcement learning, effort valuation, and action selection. Here, we review behavioral and neuroimaging studies providing evidence for impairments in these constructs in individuals with psychosis versus in individuals with depressive pathology. There are important differences in the nature of reward-related and hedonic deficits associated with psychosis versus depression that have major implications for our understanding of etiology and treatment development. In particular, the literature strongly suggests the presence of impairments in in-the-moment hedonics or "liking" in individuals with depressive pathology, particularly among those who experience anhedonia. Such deficits may propagate forward and contribute to impairments in other constructs that are dependent on hedonic responses, such as anticipation, learning, effort, and action selection. Such hedonic impairments could reflect alterations in dopamine and/or opioid signaling in the striatum related to depression or specifically to anhedonia in depressed populations. In contrast, the literature points to relatively intact in-the-moment hedonic processing in psychosis, but provides much evidence for impairments in other components involved in translating reward to action selection. Particularly, individuals with schizophrenia exhibit altered reward prediction and associated striatal and prefrontal activation, impaired reward learning, and impaired reward-modulated action selection.

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“…60 The evidence indicates that people with schizophrenia may have difficulty maintaining an emotional experience over time. 61 Consequently, due to working memory deficits, it should not be surprising that people with schizophrenia have difficulty holding on to prior emotional experiences, leading to blunting of emotional responses. This hypothesis is in accordance with previous work by Burbridge and Barch 62 who found that working memory moderated the relationship between the symptom of anhedonia and self-reported experience of enjoyment of pleasurable stimuli.…”

Section: Discussionmentioning

confidence: 99%

Working Memory Deficit as a Risk Factor for Severe Apathy in Schizophrenia: A 1-Year Longitudinal Study

Raffard

Gutierrez

Yazbek

et al. 2016

SCHBUL

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Apathy, described as impaired motivation and goal-directed behavior, is a common yet often overlooked multidimensional psychopathological state in schizophrenia. Its underlying cognitive processes remain largely unexplored. Data was drawn from a longitudinal hospital study of patients with a DSM-IV diagnosis of schizophrenia; 137 (82.5%) participated at the 1-month follow-up and 81 (59.1%) at the 1-year follow-up. Apathy was assessed with the Lille Apathy Rating Scale, validated in French and in schizophrenia. Severe apathy, overall (total score > −13) and on 4 previously identified distinct dimensions, was considered. Episodic verbal learning was assessed with the California Verbal Learning Test, executive functioning with the Trail Making Test, the Six Element Test and the Stop Signal Paradigm and working memory with the Letter-Number Sequencing Test. After controlling for confounding variables, only episodic verbal learning was associated with severe overall apathy in the cross-sectional study. At 1 year, working memory was associated with an increased risk of severe overall apathy, adjusting for baseline apathy. Using a dimensional approach to apathy, specific types of cognition were found to be associated with specific dimensions of apathy. Our findings confirm the need for a multidimensional approach of negative symptoms in schizophrenia. Moreover, cognitive functioning could be a risk factor for developing severe apathy. Cognitive remediation may thus be a useful non-pharmacological intervention for treating apathy in schizophrenia patients.

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Emotion deficits in schizophrenia: Timing matters.

Cited by 66 publications

References 58 publications

Experiential pleasure deficits in different stages of schizophrenia

Experiential pleasure deficits in different stages of schizophrenia

Mechanisms Underlying Motivational Deficits in Psychopathology: Similarities and Differences in Depression and Schizophrenia

Working Memory Deficit as a Risk Factor for Severe Apathy in Schizophrenia: A 1-Year Longitudinal Study

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