Emotion recognition and experience in Huntington's disease: Is there a differential impairment?

Ille, Rottraut; Holl, Anna K.; Kapfhammer, Hans-Peter; Reisinger, Karin; Schäfer, Axel; Schienle, Anne

doi:10.1016/j.psychres.2011.04.007

Cited by 44 publications

(28 citation statements)

References 36 publications

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“…A number of previous studies, however, have found altered self-reported emotional experiences in response to visual stimuli in individuals with HD (e.g., Paradiso et al, 2008; Eddy et al, 2011; Ille et al, 2011a). Abnormal visual scanning behavior in HD may have contributed to these previous findings.…”

Section: Discussionmentioning

confidence: 86%

“…The most frequently reported deficit is an impaired ability to identify emotions from pictures of actors posing with emotional facial expressions (e.g., Sprengelmeyer et al, 1996; Johnson et al, 2007; Labuschagne et al, 2013; Bora et al, 2016). Furthermore, many studies have found alterations in the self-reported experience of emotion in response to emotionally evocative stimuli (c.f., Mitchell et al, 2005; Paradiso et al, 2008; Eddy et al, 2011; Ille et al, 2011a; De Tommaso et al, 2013). …”

Section: Introductionmentioning

confidence: 99%

“…In contrast, when pictures of emotionally evocative scenes were used most studies found exaggerated emotional experiences in HD. Specifically, findings include exaggerated experiences of specific emotions, such as anger, fear, disgust, or happiness (Paradiso et al, 2008; Eddy et al, 2011; Ille et al, 2011a), and exaggerated experiences of arousal or valence (Paradiso et al, 2008; De Tommaso et al, 2013). Findings, however, also include a reduced experience of fear in HD (Eddy et al, 2011), as well as a lack of group differences when rating the experience of several emotions, including, disgust, happiness, or fear (Eddy et al, 2011; Ille et al, 2011b).…”

Section: Introductionmentioning

confidence: 99%

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Abnormal Visual Scanning of Emotionally Evocative Natural Scenes in Huntington’s Disease

2017

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Huntington’s disease (HD) is a neurodegenerative movement disorder associated with deficits in the processing of emotional stimuli, including alterations in the self-reported subjective experience of emotion when presented with pictures of emotional scenes. The aim of this study was to determine whether individuals with HD, compared to unaffected controls, display abnormal visual scanning of emotionally evocative natural scenes. Using eye-tracking, we recorded eye-movements of 25 HD participants (advanced pre-symptomatic and early symptomatic) and 25 age-matched unaffected control participants during a picture viewing task. Participants viewed pictures of natural scenes associated with different emotions: anger, fear, disgust, happiness, or neutral, and evaluated those pictures on a valence rating scale. Individuals with HD displayed abnormal visual scanning patterns, but did not differ from controls with respect to their valence ratings. Specifically, compared to controls, HD participants spent less time fixating on the pictures and made longer scan paths. This finding highlights the importance of taking visual scanning behavior into account when investigating emotion processing in HD. The visual scanning patterns displayed by HD participants could reflect a heightened, but possibly unfocussed, search for information, and might be linked to attentional deficits or to altered subjective emotional experiences in HD. Another possibility is that HD participants may have found it more difficult than controls to evaluate the emotional valence of the scenes, and the heightened search for information was employed as a compensatory strategy.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Abnormal Visual Scanning of Emotionally Evocative Natural Scenes in Huntington’s Disease

2017

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“…A recent study found a differential impairment in others' emotion recognition and subjective emotional involvement in HD, the former being reduced and the latter enhanced in respect to controls [12].…”

Section: Introductionmentioning

confidence: 89%

“…At the best of our knowledge, this is the first study on EEG correlates of affective images in HD, while few studies evaluated valence and arousal ratings in the same patients [12]. The late positivity we evaluated in the 400-700 msec range corresponds in healthy controls to the cortical processing following the recognition and discrimination of pictures content, expressed in the 200-400 range, and it is subtended by a specific involvement of brain areas sustaining attentive processing toward motivational significance, emotional stimuli [32].…”

Section: Lpp Amplitudementioning

confidence: 99%

EEG Correlates of Emotional Experience in Huntington’s Disease

C¹

2013

J Genet Syndr Gene Ther

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Recognizing negative emotions is impaired in Huntington's disease (HD), while the subjective emotional involvement in affective pictures images is not completely known in these patients. We aimed to further evaluate emotional reaction in early HD patients, by means of subjective arousal and valence rating and EEG changes induced by International Affective Pictures (IAPS).We recruited 16 consecutive genetically confirmed HD outpatients, and 16 sex and age matched controls. Eighty-four color slides, 28 pleasant, 28 unpleasant and 28 neutral images, in random presentation, were chosen from the International Affective Picture System. EEG was recorded by 32 scalp electrodes.HD patients judged negative and positive affective images respectively more unpleasant and pleasant than controls. They also exhibited higher arousal for pictures, independently from their affective content. However, in HD patients we observed a reduced positivity in the 400-700 m.sec intervals during unpleasant pictures viewing.Present findings may suggest that emotional impact related to affective images is preserved in HD, but it coexists with impairment of late cortical processing following unpleasant stimuli. Citation: de Tommaso M, Serpino C, Cormio C, Sciruicchio V, Franco G, et al. (2013) 4: 199. doi:10.4172/2157-7412.1000199 Page 2 of 7 Sixteen age and sex matched controls were also selected, on the basis of the exclusion of any neurological, psychiatric and general medical disorders, or CNS acting drugs use (Table 1). Journal of Genetic Syndromes & Gene TherapyEEG Correlates of Emotional Experience in Huntington's Disease. J Genet Syndr Gene Ther Experimental procedureAfter arriving at the laboratory, participants read and signed an informed consent and electrodes were attached. Patients and controls were informed on the characteristics of images and the meaning of valence and arousal rating they should assigned. They were then asked to pay attention to images, which were randomly presented. After the experimental session, participants were asked to rate all test pictures on two separate scales for valence and arousal ranging from 1 (very unpleasant, no arousal) to 9 (very pleasant, very strong arousal). Both rating scales were presented consecutively and simultaneously with the test picture on the monitor. Participants made their ratings by pressing one of the designated keys on the computer keyboard. We did not perform valence and arousal ratings during the EEG, in order to avoid movement artifacts. EEG recordingEEG was obtained by 32 scalp electrodes, by means of Micromed System Plus apparatus (Micromed, Mogliano Veneto, Italy; www. micromed-it.com) according to the international 10/20 system and the x-y-z coordinates provided by the ASA software (ASA version 4.8.1; ANT software Software, Enschede, Netherlands: http://www. ant-neuro.com). The reference electrode was placed on the nose, the ground electrode was in Fpz, and one electrode was placed above the right eyebrow for electrooculogram (EOG) recording. Impedance was ...

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Functional brain changes underlying irritability in premanifest Huntington's disease

Stock

Winter

Ahmad

et al. 2015

Human Brain Mapping

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The clinical phenotype of Huntington's disease (HD) consists of motor, cognitive and psychiatric symptoms, of which irritability is an important manifestation. Our aim was to identify the functional and structural brain changes that underlie irritability in premanifest HD (preHD). Twenty preHD carriers and 20 gene-negative controls from HD families took part in the study. Although the 5-year probability of disease onset was only 11%, the preHD group showed striatal atrophy and increased clinical irritability ratings. Functional MRI was performed during a mood induction experiment by means of recollection of emotional (angry, sad, and happy) and neutral autobiographical episodes. While there were no significant group differences in the subjective intensity of the emotional experience, the preHD group showed increased anger-selective activation in a distributed network, including the pulvinar, cingulate cortex, and somatosensory association cortex, compared to gene-negative controls. Pulvinar activation during anger experience correlated negatively with putaminal grey matter volume and positively with irritability ratings in the preHD group. In addition, the preHD group showed a decrease in anger-selective activation in the amygdala, which correlated with putaminal and caudate grey matter volume. In conclusion, compared to gene-negative controls, anger experience in preHD is associated with activity changes in a distributed set of regions known to be involved in emotion regulation. Increased activity is related to behavioral and volumetric measures, providing insight in the pathophysiology of early neuropsychiatric symptoms in preHD.

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Emotion recognition and experience in Huntington's disease: Is there a differential impairment?

Cited by 44 publications

References 36 publications

Abnormal Visual Scanning of Emotionally Evocative Natural Scenes in Huntington’s Disease

Abnormal Visual Scanning of Emotionally Evocative Natural Scenes in Huntington’s Disease

EEG Correlates of Emotional Experience in Huntington’s Disease

Functional brain changes underlying irritability in premanifest Huntington's disease

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