Aim: Polycystic ovary syndrome (PCOS) is a common endocrine-metabolic disorder. It affects women's physical well-being and leads to great psychological distress. Indeed, women with PCOS show a compromised quality of life as well as impaired emotional well-being. The aim of the present study is to assess personality characteristics, body image, and alexithymia in women with PCOS. Materials and Methods: 59 women with PCOS and 38 healthy controls were administered the Toronto Alexithymia Scale, the Body Uneasiness Test, and the Minnesota Multiphasic Personality Inventory-2. Results: The PCOS group showed higher values of alexithymia and a higher body uneasiness. They also showed higher values on many Clinical, Content, and Supplementary scales of the Minnesota Multiphasic Personality Inventory-2. Discussion: It seems that physical appearance and bodily function have a central place in the minds of women with PCOS, as well as in their relationships. However, it is a body they find it hard to feel and with which they mostly feel uncomfortable. Their approach to the outside world seems to be characterized by a certain degree of immaturity, anger, hostility, and distrust. Low 4 self-esteem also seems to be connected to a certain tendency toward introversion and withdrawal. This leads to problems in social, professional, and intimate relationships.