Emotional and behavioral symptomatology reported by help-seeking youth at clinical high-risk for psychosis

Thompson, Elizabeth; Kline, Emily; Ellman, Lauren M.; Mittal, Vijay A.; Reeves, Gloria; Schiffman, Jason

doi:10.1016/j.schres.2015.01.023

Cited by 34 publications

(29 citation statements)

References 39 publications

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“…The mean age of the patients and controls was 21.4 years and 21.9 years, respectively. With the exception of four studies using UHRÀ samples [46][47][48][49], all the other studies recruited healthy controls as comparison group. The type of risk factor, risk factor domain, sample size, type of UHR psychometric instrument are detailed in Table 1.…”

Section: Databasementioning

confidence: 99%

Deconstructing Vulnerability for Psychosis: Meta-Analysis of Environmental Risk Factors for Psychosis in Subjects at Ultra High-Risk

et al. 2016

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Section: Databasementioning

confidence: 99%

Deconstructing Vulnerability for Psychosis: Meta-Analysis of Environmental Risk Factors for Psychosis in Subjects at Ultra High-Risk

et al. 2016

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“…Recently, some studies have focused on child and adolescent PRS (Correll et al, 2008;Meyer et al, 2005;Rapado-Castro, McGorry, Yung, Calvo, & Nelson, 2015;Thompson et al, 2015;Welsh & Tiffin, 2014). However, child and adolescent samples are still small and few studies provide detailed baseline description of samples compared to healthy control (HC) groups (Tor et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Characterization of children and adolescents with psychosis risk syndrome: The Children and Adolescents Psychosis Risk Syndrome (CAPRIS) study

Dolz

Tor

Serna

et al. 2018

Early Intervention Psych

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Aim: Despite the interest in psychosis risk syndrome (PRS) in children and adolescents, information on the syndrome in this population is scarce.Methods: Prospective naturalistic multi-site study in which 10-to 17-year-old help-seeking subjects who met PRS criteria (positive or negative attenuated symptoms; brief limited intermittent psychotic symptoms; genetic risk or schizotypal personality disorder plus impairment in functioning) were included, along with 45 age and sex-matched healthy controls (HC). All subjects were clinically and functionally assessed. Results: Ninety-one PRS subjects (PRSS) with a mean age of 15.5 AE 1.4 met inclusion criteria (IC). Compared with HC, PRSS presented worse global and academic functioning in the previous year, had experienced more psychiatric and psychological problems, and presented gestational ages outside the normal range. More than 80% of PRSS met ≥2 IC, with 65.9% having one Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Text Revision diagnosis, and 61.7% of those having ≥2 diagnoses. Some 49.5% of PRSS had a first-or second-degree family history (FH) of psychosis. Patients with first-and second-degree FH do not differ in their clinical expression.Conclusions: Children and adolescents with PRS are a patient group with a pattern of neurodevelopmental impairment and clinical complexity similar to patients with schizophrenia spectrum disorders, highlighting the importance of assessing these variables in child and adolescent samples. PRSS with first-and second-degree relatives with FH do not present differences in their clinical presentation, suggesting that including these two groups of patients in the genetic risk criteria would enrich knowledge of these criteria. K E Y W O R D Schild and adolescent, clinical high risk for psychosis, psychosis, psychosis risk syndrome

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“…Research within CHR populations suggests that these patients experience considerable distress as well as impairments in social and occupational functioning well before the onset of full-threshold psychotic symptoms Ruhrmann et al, 2008;Velthorst et al, 2010;Cornblatt et al, 2011;Thompson et al, 2015). Screening may be particularly useful for identifying CHR patients at an earlier stage of illness by detecting new-onset symptoms after they have become bothersome to patients, but before they have caused notable impairments.…”

Section: Introductionmentioning

confidence: 99%

Longitudinal validation of psychosis risk screening tools

Kline

Thompson

Demro

et al. 2015

Schizophrenia Research

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Emotional and behavioral symptomatology reported by help-seeking youth at clinical high-risk for psychosis

Cited by 34 publications

References 39 publications

Deconstructing Vulnerability for Psychosis: Meta-Analysis of Environmental Risk Factors for Psychosis in Subjects at Ultra High-Risk

Deconstructing Vulnerability for Psychosis: Meta-Analysis of Environmental Risk Factors for Psychosis in Subjects at Ultra High-Risk

Characterization of children and adolescents with psychosis risk syndrome: The Children and Adolescents Psychosis Risk Syndrome (CAPRIS) study

Longitudinal validation of psychosis risk screening tools

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