Emotional and Personality Traits are Determinants of Activity Avoidance in Chronic Rhinosinusitis Patients

Epperson, Madison V.; Phillips, Katie; Speth, Marlene M.; Caradonna, David S.; Gray, Stacey T.; Sedaghat, Ahmad R.

doi:10.1002/lary.28879

Cited by 5 publications

(4 citation statements)

References 42 publications

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“…These include chronic sinonasal symptomatology 20,21 and associated exacerbations [22][23][24] which require systemic antibiotics or corticosteroids, [25][26][27][28] exacerbations of comorbid pulmonary disease, [29][30][31][32][33] and social consequences such as missed work or activity avoidance. [34][35][36][37] Sinonasal symptoms represent the dominant burden experienced by patients with CRS. 20,21 CRS disease control may be assessed based on sinonasal symptoms, the need for systemic antibiotics and corticosteroids, and the objective burden of disease on endoscopy.…”

Section: Discussionmentioning

confidence: 99%

Olfactory Dysfunction is not a Determinant Of Patient‐Reported Chronic Rhinosinusitis Disease Control

et al. 2020

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Objectives/Hypothesis: As a cardinal symptom of chronic rhinosinusitis (CRS), hyposmia has been recommended to be assessed as a component of CRS disease control. Herein we determine the significance of hyposmia in CRS in the context of nasal obstruction and drainage symptoms.Study Design: Prospective, cross-sectional Methods: Cross-sectional study of 308 CRS patients (102 CRSwNP, 206 CRSsNP) without prior endoscopic sinus surgery. The burden of nasal obstruction and hyposmia were assessed using the corresponding item scores on the 22-item Sinonasal Outcome Test (SNOT-22). Burden of nasal discharge was assessed using the mean of "thick nasal discharge" and "thick post-nasal discharge" SNOT-22 item scores. Patients were all asked to rate their CRS symptom control as "not at all," "a little," "somewhat," "very," or "completely."Results: In CRSwNP, only 4.9% had a hyposmia score > 1 with nasal obstruction and drainage scores less than or equal to 1. In CRSsNP, only 1.9% had a hyposmia score > 1 with nasal obstruction and drainage scores less than or equal to 1. On univariate association, CRS symptom control was significantly associated with nasal obstruction, hyposmia, and drainage in both CRSwNP and CRSsNP (P < .05 in all cases). Using multivariable regression to account for all nasal symptoms, only nasal obstruction and nasal discharge scores (but not hyposmia) were significantly associated with CRS symptom control.Conclusions: Hyposmia rarely occurs without nasal obstruction or nasal drainage, and may therefore be redundant to assess for CRS disease control. Moreover, hyposmia was not associated with patient-reported CRS symptom control when accounting for the burden of nasal obstruction and drainage.

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Section: Discussionmentioning

confidence: 99%

Olfactory Dysfunction is not a Determinant Of Patient‐Reported Chronic Rhinosinusitis Disease Control

et al. 2020

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“…6 Depressed mood and emotional disturbance due to CRS have also been shown to be a major determinant of missed work and school as well as activity avoidance. 7,8 Moreover, depression and anxiety are associated with worse QOL outcomes after treatment for CRS. [9][10][11] Depression and GAD in patients with CRS therefore represent 2 clinical challenges.…”

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confidence: 99%

“…Depression and anxiety have been found to worsen the patient‐perceived burden of disease 6 . Depressed mood and emotional disturbance due to CRS have also been shown to be a major determinant of missed work and school as well as activity avoidance 7 , 8 . Moreover, depression and anxiety are associated with worse QOL outcomes after treatment for CRS 9–11 .…”

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confidence: 99%

Depression and Anxiety: Considerations for Interpretation of the SNOT‐22 (22‐Item Sinonasal Outcome Test)

Phillips

Sedaghat

2021

Otolaryngol.--head neck surg.

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Objective The objective of this study was to determine whether depression and anxiety symptoms affect and confound scoring on the 22-item Sinonasal Outcome Test (SNOT-22), a commonly used outcome measure for chronic rhinosinusitis. Study Design Prospective cross-sectional. Setting Tertiary care academic center. Methods 240 participants completed the SNOT-22, from which nasal, sleep, ear/facial pain, and emotional subdomain scores were calculated. They also completed the 8-item Patient Health Questionnaire (PHQ-8) as a reflection of depression symptoms and 7-item Generalized Anxiety Disorder (GAD-7) questionnaire as a reflection of anxiety symptoms. Correlations were calculated between the 4 SNOT-22 subdomains and the PHQ-8 and GAD-7. Additionally, the predictive ability of subdomains and individual items of the SNOT-22 to predict depression and anxiety was calculated. Results The SNOT-22 sleep and emotional subdomains most strongly correlated with the PHQ-8 and the GAD-7. The emotional and sleep subdomain scores were predictive of having depression or anxiety. An emotional subdomain score ≥4 had 62.5% sensitivity and 90.1% specificity for detecting depression and 78.8% sensitivity and 88.9% specificity for detecting anxiety. A sleep subdomain score ≥21 had 81.2% sensitivity and 71.4% specificity for detecting depression and 87.9% sensitivity and 68.6% specificity for detecting anxiety. The emotional subdomain item related to sadness and the sleep subdomain items related to functional impairment were most predictive of depression and anxiety. Conclusion The SNOT-22 emotional and sleep subdomain scores may be used to predict active depression and anxiety symptoms, especially when items related to sadness or functional impairment are scored with moderate burden.

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“…Previously described, validated metrics of disease control for asthma and allergic rhinitis have included a patient-reported assessment of overall disease control as a means for direct patient input in relation to the control construct that is being measured (15)(16)(17)(18) . Because disease control is likely a complex construct, which may vary in its composition from patient to patient, and CRS has many manifestations including its associated symptomatology (19,20) , exacerbations (21)(22)(23) which require systemic antibiotics or corticosteroids (24)(25)(26)(27) , exacerbations of comorbid pulmonary disease (28)(29)(30)(31)(32) , and social consequences such as missed work or activity avoidance, patient input on assessment of control is paramount (33)(34)(35)(36) . A direct assessment of patient-reported CRS disease control that could potentially capture patients' internal synthesis of disease manifestations to form their overall disease experience may therefore serve a valuable role in a global assessment of CRS disease control.…”

Section: Discussionmentioning

confidence: 99%

Patient-reported chronic rhinosinusitis disease control is a valid measure of disease burden

Phillips¹,

Houssein²,

Singerman³

et al. 2021

Rhin

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Background: Disease control is an important treatment goal for chronic uncurable conditions such as chronic rhinosinusitis (CRS). The objective of this study was to determine whether patient-reported CRS disease control is a valid reflection of disease burden. Methods: Prospective longitudinal study of 300 CRS patients (35% CRS with nasal polyps, 65% CRS without nasal polyps). At enrollment and at a subsequent follow-up timepoint, all participants were asked to rate their CRS disease control as “not at all,” “a little,” “somewhat,” “very,” or “completely”, as well as to complete a 22-item Sinonasal Outcome Test (SNOT-22) and the 5-dimension EuroQol general health questionnaire from which the visual analogue scale (EQ-5D VAS) was used. Results: At enrollment and follow-up timepoints, patient-reported CRS disease control was significantly correlated with SNOT-22 and EQ-5D VAS scores. The change in patient-reported CRS disease control was significantly correlated with change in SNOT-22 and change in EQ-5D VAS scores. There was significant cross-sectional and longitudinal correlation between patient-reported control and all SNOT-22 subdomain scores. A SNOT-22 score of ≤ 25 points or lower, or an EQ-5D VAS score of ≥77 was predictive of having well - (i.e. “very” or “completely”) controlled CRS. Conclusions: Patient-reported CRS disease control is a valid measure of CRS disease burden and general QOL. A patient-reported assessment of CRS disease control could be considered as a component of a more comprehensive measure of CRS disease control.

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Emotional and Personality Traits are Determinants of Activity Avoidance in Chronic Rhinosinusitis Patients

Cited by 5 publications

References 42 publications

Olfactory Dysfunction is not a Determinant Of Patient‐Reported Chronic Rhinosinusitis Disease Control

Olfactory Dysfunction is not a Determinant Of Patient‐Reported Chronic Rhinosinusitis Disease Control

Depression and Anxiety: Considerations for Interpretation of the SNOT‐22 (22‐Item Sinonasal Outcome Test)

Patient-reported chronic rhinosinusitis disease control is a valid measure of disease burden

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