Emotional arousal and activation of the visual cortex: An fMRI analysis

Lang, Peter; Bradley, Margaret M.; Fitzsimmons, Jeffrey R.; Cuthbert, Bruce N.; Scott, James G.; Moulder, Bradley; Nangia, Vijay

doi:10.1017/s0048577298001991

Cited by 277 publications

(333 citation statements)

References 3 publications

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“…In the present study, there was a reduced BOLD activity in the basic response to emotional pictures of persons in social situations in extrastriate visual areas in the patients compared to healthy controls for the initial and follow-up measurement. This might be related to a reduced arousal in ALS patients, indicated by altered arousal rating in our previous and in this study, since visual areas are modulated by the visually induced emotional state [26]. Interestingly, areas which typically show a correlation of the BOLD response with emotional characteristics (valence and arousal), as has been shown in various studies in healthy controls in areas such as insula, amygdala or anterior cingulate cortex [2], showed no significant difference between ALS patients and healthy controls.…”

Section: Discussionsupporting

confidence: 49%

Brain responses to emotional stimuli in patients with amyotrophic lateral sclerosis (ALS)

et al. 2007

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Amyotrophic lateral sclerosis (ALS), a progressive motor neuron disease, affects movement and communication abilities and emotional processing. Subjective ratings of emotional stimuli depicting social interactions and facial expressions differed significantly between ALS patients and healthy controls in a previous study with a reduction of negative emotional valence (pleasantness) and lower subjective arousal (excitement) in ALS patients. In the present study, sixty similar emotional slides were presented to 13 ALS patients, 15 matched healthy controls and six tetraplegic patients. Subjective reports of valence and arousal as well as brain responses to the affective pictures using functional magnetic resonance imaging (fMRI) were measured. The picture series was presented twice with a 6-months interval to investigate effects of disease progression. ALS patients presented an increased brain response in the right supramarginal area and a reduced brain response in extrastriate visual areas at both measurements compared with healthy controls. Within the ALS patients' group a reduction of brain responses in the anterior insula at the follow-up was correlated with the subjective arousal. The reduced response in the anterior insula is tentatively interpreted as indicating reduced arousal during the course of the disease at the neural and behavioural level. The reduction of activity in extrastriate visual areas might be similarly interpreted. The increased brain response in the right supramarginal area of ALS patients might represent an altered sensitivity to social-emotional cues.

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Section: Discussionsupporting

confidence: 49%

Brain responses to emotional stimuli in patients with amyotrophic lateral sclerosis (ALS)

et al. 2007

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“…We also found more cue-induced activation of the mPFC in alcoholics than in healthy controls, which may reflect episodic memory retrieval (Lepage et al 2000). Cue-induced activation of secondary visual cortices may be associated with emotional arousal (Lang et al 1998). …”

Section: Discussionmentioning

confidence: 61%

Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics

et al. 2004

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This pilot study showed that cue-induced activation of the anterior cingulate, medial prefrontal cortex and striatum may play a role in the attribution of incentive salience to alcohol-associated stimuli, thus increasing the motivational value and attentional processing of alcohol cues. Functional brain imaging may help to identify a group of alcoholics with an otherwise undetected high risk of relapse.

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“…This approach assumes that areas of true activation stimulate signal changes over several contiguous voxels. In this study, we defined true activation as four or more immediately neighboring voxels [Lang et al, 1998;Shaywitz et al, 1995].…”

Section: Image Analysismentioning

confidence: 99%

Reduced right hemisphere activation in severely abused violent offenders during a working memory task: An fMRI study

Raine

Park

Lencz

et al. 2001

Aggressive Behavior

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This study uses functional magnetic resonance imaging (fMRI) to address two important gaps in our knowledge of brain functioning and violence: (1) What are the brain correlates of adults in the community who have suffered severe physical abuse early in life and who go on to perpetrate serious violence in adulthood? (2) What characterizes those who experience severe physical abuse but who refrain from serious violence? Four groups of participants recruited from the community (controls, severe physical child abuse only, serious violence only, and severely abused, seriously violent offenders) underwent fMRI while performing a visual/verbal working memory task. Violent offenders who had suffered severe child abuse show reduced right hemisphere functioning, particularly in the right temporal cortex. Abused individuals who refrain from serious violence showed relatively lower left, but higher right, activation of the superior temporal gyrus. Abused individuals, irrespective of violence status, showed reduced cortical activation during the working memory task, especially in the left hemisphere. Brain deficits were independent of IQ, history of head injury, task performance, cognitive strategy, and mental activity during the control task. Findings constitute the first fMRI study of brain dysfunction in violent offenders, and indicate that initial right hemisphere dysfunction, when combined with the effects of severe early physical abuse, predisposes to serious violence but that relatively good right hemisphere functioning protects against violence in physically abused children. Aggr. Behav. 27:111-129, 2001.

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Emotional arousal and activation of the visual cortex: An fMRI analysis

Cited by 277 publications

References 3 publications

Brain responses to emotional stimuli in patients with amyotrophic lateral sclerosis (ALS)

Brain responses to emotional stimuli in patients with amyotrophic lateral sclerosis (ALS)

Cue-induced activation of the striatum and medial prefrontal cortex is associated with subsequent relapse in abstinent alcoholics

Reduced right hemisphere activation in severely abused violent offenders during a working memory task: An fMRI study

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