Being a grandparent is an important social role for Chinese older adults. Despite an increasing number of older Chinese immigrants in the United States and the uniquely differing culture of the United States relative to Chinese culture, few studies focused specifically on Chinese immigrant families in the United States. By conducting four focus groups (n = 32) in Los Angeles, CA, this study aimed to explore grandparent–grandchild relationships in Chinese immigrant families in the U.S. We found that the majority of Chinese immigrant grandparents maintained close relationships with their grandchildren. Grandparents’ adjustments of acculturation played an important role in maintaining close relationships with their grandchildren through improved English language proficiency, acceptance of American culture, and adjusted expectations. In addition, the middle generation acted as instructors, models, and interpreters in grandparent–grandchild relationships. The study contributed to literature by finding that Chinese immigrant grandparents and middle generation parents play important roles in their grandchildren’s lives via cohesive relationships. Practical services or programs can consider decreasing the acculturation gaps with grandchildren and linking three generations together when strengthening grandparent-grandchild relationships in the United States.