Emotional distress in haemophilia: Factors associated with the presence of anxiety and depression symptoms among adults

Pinto, Paulo Daniel Araújo; Paredes, Ana Cristina; Moreira, Pedro Silva; Fernandes, Susana; Lopes, Marcelo Coelho; Carvalho, Manuela; Almeida, Armando

doi:10.1111/hae.13548

Cited by 29 publications

(61 citation statements)

References 56 publications

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“…furthermore, patients can continue the prophylactic treatment by reducing the number of weekly infusions without compromising the protection from bleeding episodes, all with a long-term impact on the state of the joints, adherence to therapy and quality of life. The reduction in the number of infusions is the requirement that our patients have always emphasized and now we have the concrete possibility of offering it, creating the conditions for an improvement in adherence to therapy with a significant positive impact on the quality of life of patients, with no differences about surgery protocols [14,42,43,44,45,46,47,48,49,50,51]. At last only 7 studies were included because on human science field (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Surgical Risk on Patients with Coagulopathies: Guidelines on Hemophiliac Patients for Oro-Maxillofacial Surgery

Laino

Cicciù

Fiorillo

et al. 2019

IJERPH

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Background: Haemophilia is a disease of genetic origin, which causes a defect in blood coagulation. Under normal conditions, in the case of leakage from the blood vessels, the blood forms a clot that reduces or blocks the bleeding. This process involves the activation of several plasma proteins in a cascade-like species. Two of these proteins, produced in the liver, factor VIII and factor IX, are deficient or present a functional defect in people with haemophilia. Because of this deficit, the haemophiliacs easily suffer external and internal bleeding. Surgical treatment of these patients is to be observed, and often their treatment is delayed due to unclear guidelines and risks in treating these patients. The aim is to provide clear guidelines in the case of surgical treatment of these patients. Methods: In this study, we have considered all the guidelines that refer to the gold-maxillofacial surgery, focusing on the literature of the last 10 years. Results: Surely, this collection of guidelines will favor the choice of the clinician towards safer and predictable protocols. This study does not want to create a guideline but evaluates the literature of the last 10 years, and highlights the latest for the treatment of these patients., with the aim of informing the pathology and at the same time making the surgical maneuvers safer. Conclusions: Despite the research of literature has produced few results, it was nevertheless possible to draw up a guideline thanks to additional information extrapolated from textbooks and other scientific articles. According to the guidelines, it is possible to proceed to the treatment of these patients, if with appropriate therapy in a safe and risk-free manner.

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Section: Discussionmentioning

confidence: 99%

Surgical Risk on Patients with Coagulopathies: Guidelines on Hemophiliac Patients for Oro-Maxillofacial Surgery

Laino

Cicciù

Fiorillo

et al. 2019

IJERPH

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“…Congruently, previous findings of our team have shown that the greatest pain interference reported by Portuguese PWH was on dimensions related to daily activities, such as work and mobility, but also on mood 13 . In this scope, a positive association between pain interference and distress was also found among PWH, heightening the relevance of interventions that target pain interference in this population 56 . This body of evidence and our current findings add to recent publications calling for an improvement on pain management among PWH, namely through a broader adoption of non-pharmacological strategies 7,14,16,17 .…”

Section: Discussionmentioning

confidence: 77%

Effectiveness of hypnosis for pain management and promotion of health-related quality-of-life among people with haemophilia: a randomised controlled pilot trial

Paredes

Costa

Fernandes

et al. 2019

Sci Rep

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Joint deterioration and associated chronic pain are common among people with haemophilia (PWH), having an impact on quality-of-life. Though non-pharmacological strategies are recommended, psychological interventions to promote pain control and quality-of-life have scarcely been tested in haemophilia. This randomised controlled pilot trial aimed to assess feasibility, acceptability and effectiveness of hypnosis for pain management and promotion of health-related quality-of-life (HRQoL) among PWH. Twenty adults were randomised either to four weekly hypnosis sessions plus treatment-as-usual (experimental group; EG) or treatment-as-usual only (control group; CG). Participants completed sociodemographic and clinical assessment, measures of pain, HRQoL and emotional distress before (T1) and after (T2) intervention. Changes were analysed by calculating the differences between T1 and T2, and the groups were compared through independent-sample t tests (or chi-squared). Retention rates (90%) and analysis of patient satisfaction showed good acceptability and feasibility of the intervention. The EG (n = 8) had a higher reduction on pain interference than the CG (n = 10) (d = −0.267). A higher improvement on HRQoL (EQ-5D index: d = 0.334; EQ-5D VAS: d = 1.437) and a tendency towards better haemophilia-related quality-of-life (A36-Hemofilia QoL) were also evident in the EG. This is the first study showing the effectiveness of hypnosis to reduce pain interference and promote HRQoL among PWH.

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“…Hemophilia involves psychosocial aspects that are associated with increased emotional distress that can affect health outcomes [36]. This aspect is particularly worrisome, given that during the pandemic there have been rates of anxiety and depression of 16%-28% among the general population, linked to social isolation, fears of infection, loss of work, or changes in routine [37].…”

Section: Mental Health Considerationsmentioning

confidence: 99%

What COVID-19 can mean for people with hemophilia beyond the infection risk

Corte‐Rodríguez¹,

Álvarez‐Román²,

Rodríguez-Merchán³

et al. 2020

Expert Review of Hematology

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Introduction: The coronavirus disease 2019 (COVID-19) pandemic represents an unprecedented global health crisis. To combat its effects, many governments have opted for strategies of social isolation that involve a radical change in people's behavior. Areas covered: For patients with hemophilia, the negative consequences of these measures can be greater, given they modify aspects of health care and lifestyles needed to counteract the adverse effects of hemophilia. The long-term consequences of the pandemic on patients with hemophilia are not well known. The aim of this special report is to show what COVID-19 could mean for this population, beyond the risk of infection. Expert opinion: Considerations of the clinical, care, therapeutic, physical, nutritional, mental health, pain, and disability aspects that might be affected are included. Strategies are also suggested to minimize the effects that these issues can have on patients' lives. Patients, health professionals, and society as a whole must work together to mitigate the effects of the pandemic on people with hemophilia.

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Emotional distress in haemophilia: Factors associated with the presence of anxiety and depression symptoms among adults

Cited by 29 publications

References 56 publications

Surgical Risk on Patients with Coagulopathies: Guidelines on Hemophiliac Patients for Oro-Maxillofacial Surgery

Surgical Risk on Patients with Coagulopathies: Guidelines on Hemophiliac Patients for Oro-Maxillofacial Surgery

Effectiveness of hypnosis for pain management and promotion of health-related quality-of-life among people with haemophilia: a randomised controlled pilot trial

What COVID-19 can mean for people with hemophilia beyond the infection risk

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