“…Moreover, psychological aspects may also drive individual behavior, including adherence to medical advice, deeply conditioning the management of chronic diseases (Marchini et al, 2020 , 2021a , b ). Anxiety and depression, emotional distress (e.g., alexithymia, abnormal disgust processing), body integrity identity disorders, cognitive deficits, lead to a variety of functional somatic disorders and affect a patient's attitude to treatment, which can impact their perceived quality of life (Vicario, 2013 ; Craparo et al, 2016 ; Di Giuseppe et al, 2019 ; Conversano et al, 2020 ; Martino et al, 2020 ; Barchetta et al, 2021 ; Gangemi et al, 2021 ; La Rosa et al, 2021 ; Liotta et al, 2021 ; Vicario et al, 2021 ; Martino et al ).…”