Emotional dysregulation, alexithymia and neuroticism: a systematic review on the genetic basis of a subset of psychological traits

Abstract

Neuroticism, alexithymia and emotion dysregulation are key traits and known risk factors for several psychiatric conditions. In this systematic review, the aim is to evaluate the genetic contribution to these psychological phenotypes. A systematic review of articles found in PubMed was conducted. Search terms included ‘genetic’, ‘GWAS’, ‘neuroticism’, ‘alexithymia’ and ‘emotion dysregulation’. Risk of bias was assessed utilizing the STREGA checklist. Two hundred two papers were selected from existing literature based on the inclusion and exclusion criteria. Among these, 27 were genome-wide studies and 175 were genetic association studies. Single gene association studies focused on selected groups of genes, mostly involved in neurotransmission, with conflicting results. GWAS studies on neuroticism, on the other hand, found several relevant and replicated intergenic and intronic loci affecting the expression and regulation of crucial and well-known genes (such as DRD2 and CRHR1). Mutations in genes coding for trascriptional factors were also found to be associated with neuroticism (DCC, XKR6, TCF4, RBFOX1), as well as a noncoding regulatory RNA (LINC00461). On the other hand, little GWAS data are available on alexythima and emotional dysregulation.

Stress-related cellular pathophysiology as a crosstalk risk factor for neurocognitive and psychiatric disorders

“…Resaerchers have also found that COMT is associated with emotional dysregulation and that dopamine receptor 2 genes can be a promising target of antipsychotic medications [e.g., 331 ]. Additionally, for monoamine oxidase A, H allele carriers have greater stress effects on the right anterior hippocampus hypoactivity and cortisol hyperresponse as compared to the L allele carriers [ 332 ].…”