Emotional Dysregulation in Psychogenic Voice Loss

Spengler, Franny B.; Becker, Benjamin; Kendrick, Keith M.; Conrad, Rupert; Hurlemann, René; Schade, G.

doi:10.1159/000452306

Cited by 16 publications

(6 citation statements)

References 8 publications

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“…Anxiety and depression have been associated with amygdala functional networks ( Spengler et al, 2017a ; Zhao et al, 2019b ; Xu et al, 2021 ; Liu et al, 2021b ), and therefore corresponding indices were assessed to control for pretreatment differences between the groups. To this end, the State-Trait Anxiety Inventory ( Spielberger et al, 1970 ) and Beck Depression Inventory ( Beck et al, 1996 ) were applied.…”

Section: Methodsmentioning

confidence: 99%

Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms

Lan

Liu

et al. 2022

International Journal of Neuropsychopharmacology

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Background The hypothalamic neuropeptide oxytocin (OXT) may exert anxiolytic and stress-reducing actions via modulatory effects on amygdala circuits. Animal models and initial findings in humans suggest that some of these effects are mediated by interactions with other neurotransmitter systems, in particular the serotonin (5-HT) system. Against this background, the present pharmacological resting state fMRI study aimed at determining whether effects of OXT on stress-associated amygdala intrinsic networks are mediated by 5-HT. Methods We employed a randomized placebo-controlled double-blind parallel-group pharmacological fMRI resting state experiment with four treatment groups in n = 112 healthy male participants. Participants underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD) or a corresponding placebo-control protocol (ATDc) before the administration of intranasal OXT (24 International Units) or placebo intranasal spray. Results OXT and 5-HT modulation exerted interactive effects on the coupling of the left amygdala with the ipsilateral hippocampus and adjacent midbrain. OXT increased intrinsic coupling in this pathway, while this effect of OXT was significantly attenuated during transiently decreased central serotonergic signaling induced via ATD. In the absence of OXT or 5-HT modulation this pathway showed a trend for an association with self-reported stress perception in everyday life. No interactive effects were observed for the right amygdala. Conclusions Together, the findings provide first evidence that effects of OXT on stress-associated amygdala-hippocampal-midbrain pathways are critically mediated by the 5-HT system in men.

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Section: Methodsmentioning

confidence: 99%

Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms

Lan

Liu

et al. 2022

International Journal of Neuropsychopharmacology

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show abstract

“…Anxiety and depression have been associated with amygdala functional networks (Spengler et al, 2017a; Zhao et al, 2019b; Xu et al, 2021; Liu et al, 2021b) and therefore corresponding indices were assessed to control for pre-treatment differences between the groups. To this end the State-Trait Anxiety Inventory (STAI) (Spielberger et al, 1970) and Beck Depression Inventory (BDI-II) (Beck et al, 1996) were applied.…”

Section: Methodsmentioning

confidence: 99%

Oxytocinergic modulation of stress-associated amygdala-hippocampus pathways in humans is mediated by serotonergic mechanisms

Lan¹,

Liu

et al. 2021

Preprint

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BackgroundThe hypothalamic neuropeptide oxytocin (OXT) may exert anxiolytic and stress-reducing actions via modulatory effects on amygdala circuits. Animal models and initial findings in humans suggest that some of these effects are mediated by interactions with other neurotransmitter systems, in particular the serotonin (5-HT) system. Against this background, the present pharmacological resting state fMRI study aimed at determining whether effects of OXT on stress-associated amygdala intrinsic networks are mediated by 5-HT.MethodsWe employed a randomized placebo-controlled double-blind parallel-group pharmacological fMRI resting state experiment during which n = 112 healthy male participants underwent a transient decrease in 5-HT signaling via acute tryptophan depletion (ATD+) or the corresponding placebo-control protocols (ATD-) before the administration of intranasal OXT or placebo intranasal spray, respectively.ResultsOXT and 5-HT modulation exerted interactive effects on the coupling of the left amygdala with the ipsilateral hippocampus and adjacent midbrain. OXT increased intrinsic coupling in this pathway, while this effect of OXT was significantly attenuated during transiently decreased central serotonergic signaling induced via ATD+. In the absence of OXT or 5-HT modulation this pathway was associated with self-reported stress perception in everyday life, while an OXT-induced modulation of this pathway was following ATD- pre-treatment.ConclusionsTogether, the findings provide first evidence that effects of OXT on stress-associated amygdala-hippocampal-midbrain pathways are critically mediated by the 5-HT system in men.

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“…The LMT literature lacks broader views regarding mechanisms of action and effect, though a few newer papers [16,17] look at potential mechanisms through brain-based changes from peripheral manipulations via fMRI studies, introducing a more complex tapestry of impact…”

Section: Introductionmentioning

confidence: 99%

The mechanism of action for laryngeal manual therapies: the need for an update

Fritz

2024

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of review To propose a pathway for expanding the understanding of potential mechanisms of action with laryngeal-based manual therapy (LMT) for muscle tension dysphonia (MTD). This review may help determine if current LMT literature has kept up with advances in the more general manual therapy (MT) findings. Recent findings Studies over the past thirty years, including recently published articles, have confirmed the efficacy of various manual therapy interventions in treating MTD. However, gaps exist between current LMT literature and that being presented in the more general MT field. Instead of viewing peripheral manipulation's influences as a local cause/effect process, the MT literature paints a richer tapestry of centrally mediated impacts. Summary Evidence from outside the LMT field has introduced a broad tapestry of factors that may contribute to the efficacy of MT, extending beyond the local effects reported in LMT literature. To better understand the effect and mechanism of action touch-based interventions have on a patient's voice and to potentially improve outcomes, it is necessary to broaden investigations to include a broader range of perspectives.

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Emotional Dysregulation in Psychogenic Voice Loss

Cited by 16 publications

References 8 publications

Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms

Oxytocinergic Modulation of Stress-Associated Amygdala-Hippocampus Pathways in Humans Is Mediated by Serotonergic Mechanisms

Oxytocinergic modulation of stress-associated amygdala-hippocampus pathways in humans is mediated by serotonergic mechanisms

The mechanism of action for laryngeal manual therapies: the need for an update

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