Emotional facial expression processing in depression: Data from behavioral and event-related potential studies

Delle-Vigne, Dyna; Wang, W.; Kornreich, Charles; Verbanck, Paul; Campanella, Salvatore

doi:10.1016/j.neucli.2014.03.003

Cited by 41 publications

(34 citation statements)

References 182 publications

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“…Although recent priming studies using picture paradigms have demonstrated alterations in the P300, LPP and N400 ERP waveforms with respect to depression (in non-PD samples), the direction of the alterations were contrary to our findings. Previous literature (Cermolacce et al, 2014;Delle-Vigne et al, 2014;Hu et al, 2017;Li et al, 2018) suggests that depressed individuals show larger ERP amplitudes for negative compared to neutral targets and therefore, we expected a larger difference wave for evaluative judgements on target words when comparing negative with neutral prime or target words. Our results may suggest PD-specific emotional deficits, specifically PD-specific deficits in initiating emotional judgements in PD patients with high depression score.…”

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confidence: 84%

“…Similarly, the N400 (an ERP component relevant to word processing) generated for target word stimuli was larger for negative compared to neutral primes when followed by neutral target words (Negative-Neutral prime target pair compared to Neutral-Neutral condition) in both groups, suggesting automatic processing of negative information are intact in PD patients with no affective disturbances. The present study examines how the P300 and LPP, well known ERP components associated with emotion processing (Cermolacce et al, 2014;Delle-Vigne et al, 2014;Hu et al, 2017;Li et al, 2018), as well as the N400 component related to word processing, are moderated by depressive symptoms in PD (Kutas and Federmeier, 2011).…”

Section: Accepted Manuscriptmentioning

confidence: 95%

“…A reduction in P300 has been demonstrated with depression using auditory oddball paradigms, suggesting deficits in evaluation, attentional allocation and short term memory encoding (Jaworska and Protzner, 2013). On the other hand, priming studies using picture (faces) paradigms have demonstrated larger P300, LPP and N400 amplitude for negative stimuli in depression (Bistricky et al, 2014;Cermolacce et al, 2014;Delle-Vigne et al, 2014;Hu et al, 2017;Li et al, 2018), suggesting difficulty in disengaging with negative information in depressed persons. Against this background, it is hypothesized that ERP components, P300, LPP and N400 will demonstrate amplitude modulations between negative and neutral target words, that the valence of the preceding prime word will also influence the ERPs generated for the target stimuli, and that depression scores modulate the ERP waveforms.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Depression symptomatology correlates with event-related potentials in Parkinson's disease: An affective priming study

Dissanayaka

Angwin

et al. 2019

Journal of Affective Disorders

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BackgroundDepression is a predominant non-motor symptom of Parkinson's disease (PD), which is often under recognised and undertreated. To improve identification of depression in PD it is imperative to examine objective brain-related markers. The present study addresses this gap by using electroencephalography (EEG) to evaluate the processing of emotionally valanced words in PD. MethodsFifty non-demented PD patients, unmedicated for depression or anxiety, completed an affective priming task while EEG was simultaneously recorded. Prime and target word pairs of negative or neutral valence were presented at a short 250ms stimulus onset asynchrony. Participants were asked to evaluate the valence of the target word by button press. Depression was measured using an established rating scale. Repeated measures analysis of covariance and correlational analyses were performed to examine whether event-related potentials (ERP) varied as a function of depression scores. ResultsKey ERP findings reveal reduced responses in parietal midline P300, N400 and Late Positive Potential (LPP) difference waves between congruent and incongruent neutral targets in patients with higher depression scores. LimitationsComparisons of ERPs were limited by insufficient classification of participants with and without clinical depression. A majority of PD patients who had high depression scores were excluded from the analysis as they were receiving antidepressant and/or anxiolytic medications which could interfere with ERP sensitivity.The present study suggests that the Pz-P300, N400 and LPP are ERP markers relates to emotional dysfunction in PD. These findings thus advance current knowledge regarding the neurophysiological markers of a common neuropsychiatric deficit in PD.

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confidence: 84%

Section: Accepted Manuscriptmentioning

confidence: 95%

Section: Accepted Manuscriptmentioning

confidence: 99%

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Depression symptomatology correlates with event-related potentials in Parkinson's disease: An affective priming study

Dissanayaka

Angwin

et al. 2019

Journal of Affective Disorders

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“…As emotional processes are disrupted in depression 96,97 and knowing the high incidence of depression in PD, 7,98 it has been suggested that FER deficit is not specific to PD but is linked to mood disorders. The studies we reviewed usually controlled for this aspect by selecting patients with normal depression scores and/or directly testing the effect of depression on performance.…”

Section: Mood Disordersmentioning

confidence: 99%

Facial emotion recognition in Parkinson's disease: A review and new hypotheses

et al. 2018

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Parkinson's disease is a neurodegenerative disorder classically characterized by motor symptoms. Among them, hypomimia affects facial expressiveness and social communication and has a highly negative impact on patients' and relatives' quality of life. Patients also frequently experience nonmotor symptoms, including emotional‐processing impairments, leading to difficulty in recognizing emotions from faces. Aside from its theoretical importance, understanding the disruption of facial emotion recognition in PD is crucial for improving quality of life for both patients and caregivers, as this impairment is associated with heightened interpersonal difficulties. However, studies assessing abilities in recognizing facial emotions in PD still report contradictory outcomes. The origins of this inconsistency are unclear, and several questions (regarding the role of dopamine replacement therapy or the possible consequences of hypomimia) remain unanswered. We therefore undertook a fresh review of relevant articles focusing on facial emotion recognition in PD to deepen current understanding of this nonmotor feature, exploring multiple significant potential confounding factors, both clinical and methodological, and discussing probable pathophysiological mechanisms. This led us to examine recent proposals about the role of basal ganglia‐based circuits in emotion and to consider the involvement of facial mimicry in this deficit from the perspective of embodied simulation theory. We believe our findings will inform clinical practice and increase fundamental knowledge, particularly in relation to potential embodied emotion impairment in PD. © 2018 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

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“…On neurophysiologic performance depressed people seem to exhibit disturbed P300 component (reduced and slower P300 for happy faces) [53] and, faster P3b in individual with anxious tendencies [54]. An affective negative bias is observed: they can't avoid attending to negative information in their environment [55] and has higher P1 and P2 amplitude for sad faces compared with other faces [56].…”

Section: Reviewmentioning

confidence: 99%

Social Impairment and Mental Health

Nuñez¹

2017

Ann of Behav Sci

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Stress resulting from living in large cities (and alienation in certain individuals) fuels the high incidence of psychiatric illnesses in modern metropolises. Some pathology as Schizophrenia and Asperger has deficits on social cognition mechanisms and its presentation may be influenced by social environmental impact. Even more, common mental disease such as depression and personality disorders has a great impact by environmental social deficits and present poor social cognition performances on some specific areas. The purpose of current brief review is to provide an overview of the mechanisms who impacts on social relationships (social cognition) and the effects of social deprivation in people with mental illness.

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Emotional facial expression processing in depression: Data from behavioral and event-related potential studies

Cited by 41 publications

References 182 publications

Depression symptomatology correlates with event-related potentials in Parkinson's disease: An affective priming study

Depression symptomatology correlates with event-related potentials in Parkinson's disease: An affective priming study

Facial emotion recognition in Parkinson's disease: A review and new hypotheses

Social Impairment and Mental Health

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