This research examines the relationship between metadehumanization, that is, perceiving dehumanizing treatments, and self-dehumanization, that is, perceiving oneself as less than human. We argue that, in work settings, this relationship can be explained through a behavioral mechanism. Specifically, organizational metadehumanization would drive employees to engage in more emotional labor (i.e., surface acting), which, in turn, would generate mechanistic self-dehumanizing perceptions. Our hypothesized mediation model is tested across three studies. First, a cross-sectional field study shows that organizational metadehumanization is positively related to surface acting, which is in turn positively associated with mechanistic self-dehumanizing perceptions. Second, an experimental study, manipulating the level of organizational metadehumanization through vignettes, confirms that the more employees feel dehumanized by their organization, the more they engage in surface acting, which, in turn, leads to mechanistic self-dehumanizing perceptions. Third, a longitudinal field study with repeated measures corroborates that the use of surface acting conducts employees to perceive mechanistic self-dehumanization. Overall, these findings highlight that metadehumanization in the workplace is critical in the way employees manage their emotions, which is determinant in the development of mechanistic self-dehumanizing perceptions.