Emotional perception modulated by an opioid and a cholecystokinin agonist

Gospic, Katarina; Gunnarsson, Tove; Fransson, Peter; Ingvar, Martin; Lindefors, Nils; Petrović, Predrag

doi:10.1007/s00213-007-1032-4

Cited by 34 publications

(32 citation statements)

References 57 publications

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“…After the stimulus encoding stage, arousal hence contributes to memory consolidation (Anderson et al 2006;Kleinsmith and Kaplan 1963). Hence, the emotional arousal value of stimuli contributes to improved memory for these stimuli (Gospic et al 2008;Ochsner 2000).…”

Section: Introductionmentioning

confidence: 98%

Effects of oxazepam on affective perception, recognition, and event-related potentials

et al. 2011

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Section: Introductionmentioning

confidence: 98%

Effects of oxazepam on affective perception, recognition, and event-related potentials

et al. 2011

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“…Positive affective states are associated with enhanced opioidergic activity (Boecker et al, 2008;Koepp et al, 2009) and negative states with its deactivation (Zubieta et al, 2003). Also, the hedonic responses to external emotional stimuli, such as sweet taste (Berridge, 2003), IAPS pictures (Gospic et al, 2008), and monetary reward , were shown to be modulated by opioids. In our study, mood and subjective ratings of experienced affective states during pleasant-picture viewing were not significantly influenced by naloxone.…”

Section: Discussionmentioning

confidence: 99%

“…For example, whereas sustained sadness was associated with a deactivation in -opioid neurotransmission (Zubieta et al, 2003), euphoric mood states were inversely correlated with opioid binding in prefrontal/orbitofrontal cortices (Boecker et al, 2008). Moreover, opioids seem to be implicated in the hedonic response to pleasant sensory and emotional stimuli, such as sweet taste (Berridge, 2003;Peciña, 2008) or visual stimuli (Gospic et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Pleasure-Related Analgesia Activates Opioid-Insensitive Circuits

Kut

Candia²,

Overbeck³

et al. 2011

J. Neurosci.

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Recent findings suggest that pain and pleasure share common neurochemical circuits, and studies in animals and humans show that opioid-mediated descending pathways can inhibit or facilitate pain. We explored the role of endogenous opioid neurotransmission in pleasure-related analgesia. -Opioidergic activity was blocked with 0.2 mg/kg naloxone to assess its effects on hedonic responses to pleasant emotional pictures (International Affective Picture System) and its modulating effects on heat pain tolerance. Naloxone did not alter subjective and autonomous reactions to pleasure induction or overall mood of participants. In addition, pleasure-related increases in pain tolerance persisted after reversal of endogenous -opioidergic neurotransmission. Subjective pain intensity and unpleasantness ratings increased after naloxone administration. These findings suggest that, in addition to opioid-sensitive circuits, mainly opioidinsensitive pain-modulating circuits are activated during pleasure-related analgesia.

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“…It can be speculated that the placebo-nocebo phenomenon is a continuum, with opioid and CCK-ergic systems acting as the mediators of opposing effects. Opposing effects of these two systems are well documented also for mood disorders [37] and have been described also in the emotional modulation of other external signals, like visual input [38].…”

Section: Three Neurotransmitters Have Been Identified In Placebo Analmentioning

confidence: 92%

Placebo mechanisms across different conditions: from the clinical setting to physical performance

Pollo

Carlino

Benedetti

2011

Phil. Trans. R. Soc. B

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Although the great increase in interest in the placebo phenomenon was spurred by the clinical implications of its use, the progressive elucidation of the neurobiological and pharmacological mechanisms underlying the placebo effect also helps cast new light on the relationship between mind (and brain) and body, a topic of foremost philosophical importance but also a major medical issue in light of the complex interactions between the brain on the one hand and body functions on the other. While the concept of placebo can be a general one, with a broad definition generally applicable to many different contexts, the description of the cerebral processes called into action in specific situations can vary widely. In this paper, examples will be given where physiological or pathological conditions are altered following the administration of an inert substance or verbal instructions tailored to induce expectation of a change, and explanations will be offered with details on neurotransmitter changes and neural pathways activated. As an instance of how placebo effects can extend beyond the clinical setting, data in the physical performance domain and implications for sport competitions will also be presented and discussed.

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Emotional perception modulated by an opioid and a cholecystokinin agonist

Abstract: This study shows that the CCK and the opioid system modulate how external stimuli are emotionally perceived, suggesting a possible involvement in affective disorders.

Cited by 34 publications

References 57 publications

Effects of oxazepam on affective perception, recognition, and event-related potentials

Effects of oxazepam on affective perception, recognition, and event-related potentials

Pleasure-Related Analgesia Activates Opioid-Insensitive Circuits

Placebo mechanisms across different conditions: from the clinical setting to physical performance

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