High-pressure processing (HPP) represents a sustainable
and gentle
preservation technique. Since the effects of processing parameters
are still poorly reported for lipophilic, bioactive ingredients (e.g.,
vitamin E and carotenoids), the present study covers a comprehensive
set of HP applications using laboratory-, pilot-, and industrial-scale
plants to evaluate nutritional aspects such as compound extractabilities,
bioaccessibilities, and antioxidant capacities. Low-pressure regimes
increased extractabilities of vitamin E in kale at 10 MPa (+105%)
and at 50 MPa (+102%). Multicycle processing had no significant contribution
to the extractability of target compounds. Thermally processed samples
(40–80 °C) at 600 MPa retained major chlorophyll content
in contrast to depletion after heat sterilization (121 °C). HPP
improved the bioaccessibilities of vitamin E, lutein, and β-carotene
even at 600 MPa (80 °C). Industrial-scale samples at high-pressure,
low-temperature showed a more fresh-like texture elicited by a reduced
need for sample comminution and optimal conditions for increased extractabilities
of target compounds.