BackgroundCannabis dependence is a significant public health problem. Because there are
no approved medications for this condition, treatment must rely on
behavioral approaches empirically complemented by such lifestyle change as
exercise.AimsTo examine the effects of moderate aerobic exercise on cannabis craving and
use in cannabis dependent adults under normal living conditions.DesignParticipants attended 10 supervised 30-min treadmill exercise sessions
standardized using heart rate (HR) monitoring (60–70% HR
reserve) over 2 weeks. Exercise sessions were conducted by exercise
physiologists under medical oversight.ParticipantsSedentary or minimally active non-treatment seeking cannabis-dependent adults
(n = 12, age 25±3 years, 8 females) met criteria
for primary cannabis dependence using the Substance Abuse module of the
Structured Clinical Interview for DSM-IV (SCID).MeasurementsSelf-reported drug use was assessed for 1-week before, during, and 2-weeks
after the study. Participants viewed visual cannabis cues before and after
exercise in conjunction with assessment of subjective cannabis craving using
the Marijuana Craving Questionnaire (MCQ-SF).FindingsDaily cannabis use within the run-in period was 5.9 joints per day
(SD = 3.1, range 1.8–10.9). Average cannabis use
levels within the exercise (2.8 joints, SD = 1.6, range
0.9–5.4) and follow-up (4.1 joints, SD = 2.5,
range 1.1–9.5) periods were lower than during the run-in period (both
P<.005). Average MCQ factor scores for the pre- and post-exercise craving
assessments were reduced for compulsivity (P = .006),
emotionality (P = .002), expectancy (P
= .002), and purposefulness (P
= .002).ConclusionsThe findings of this pilot study warrant larger, adequately powered
controlled trials to test the efficacy of prescribed moderate aerobic
exercise as a component of cannabis dependence treatment. The
neurobiological mechanisms that account for these beneficial effects on
cannabis use may lead to understanding of the physical and emotional
underpinnings of cannabis dependence and recovery from this disorder.Trial RegistrationClinicalTrials.gov NCT00838448]