Community-based organizations (CBOs) have played a vital role in containing the infections of the COVID-19 pandemic as well. They serve as a facilitator between communities, local health officials, and the entire administration by providing information about the feasibility and viability of proposed mitigation strategies and later help them to operationalize these strategies. This chapter discusses how CBOs should continually access the situation and modify their operations to carry forward their objectives in order to protect their staff and various stakeholders. It reflects on the way these CBOs have tackled these challenges and worked for the benefit of people. It discusses the new models and examples of success that have been shown by these organizations. This chapter is written on the basis of secondary data. It deliberates on the initiatives taken by the CBOs during and post-pandemic. It also discusses the opportunities for growth these organizations have during this global health crisis and the challenges they are facing for their survival during and after the pandemic.