Emperipolesis-like Invasion of Neoplastic Lymphocytes into Hepatocytes in Feline T-cell Lymphoma

Suzuki, Minoru; Kanae, Yutaka; Kagawa, Yumiko; Ano, N.; Nomura, Kohji; Ozaki, Kiyokazu; Narama, Isao

doi:10.1016/j.jcpa.2010.10.005

Cited by 15 publications

(18 citation statements)

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“…Invasion of hepatic cords by neoplastic lymphocytes has been described in cats. 15,17 The pattern of liver involvement in cats was identical to that in dogs in the present study. However, most feline cases described to date lack comprehensive clinical, clinicopathologic, and pathological data.…”

Section: Discussionsupporting

confidence: 80%

“…Similarly, involvement of the spleen was not emphasized in previous reports of feline lymphoma similar to HC-TCL, although spleen was available only in 2 of 14 total cats. 15,17 A primary hepatic origin would also be consistent with the liver's role as an organ with predominantly innate immunity and relatively high numbers of gd T cells. 7 However, antigen loss by neoplastic cells cannot be ruled out, and careful assessment of organ involvement in future cases is needed to fully elucidate this question.…”

Section: Discussionmentioning

confidence: 80%

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Hepatosplenic and Hepatocytotropic T-Cell Lymphoma

et al. 2012

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The clinical, clinicopathologic, and pathological findings of 9 dogs with T-cell lymphoma that involved the liver in the absence of peripheral lymphadenopathy were assessed. Seven dogs had hepatosplenic T-cell lymphoma (HS-TCL). Dogs with HS-TCL presented with hepato- and/or splenomegaly, regenerative anemia, thrombocytopenia, and hypoproteinemia. The clinical course was rapidly progressive with all dogs but 1 dead within 24 days of initial presentation. Neoplastic lymphocytes were centered on hepatic and splenic sinusoids and had a CD3+ (5/7), TCRαβ– (5/5), TCRγδ+ (3/5), CD11d+ (6/7), granzyme B+ (5/7) immunophenotype. Bone marrow and lungs were consistently but variably involved. These findings closely resemble the human disease and support the classification of HS-TCL as a distinct World Health Organization entity in dogs. The remaining 2 dogs markedly differed in the pattern of hepatic involvement by neoplastic lymphocytes, which were not confined to hepatic sinusoids but invaded hepatic cords. In addition, neoplastic cells had a CD11d– immunophenotype, and clinicopathologic data indicated marked cholestasis and mild to absent anemia. Based on the distinct tropism of neoplastic lymphocytes for hepatocytes, the name hepatocytotropic T-cell lymphoma (HC-TCL) is proposed. Given the histomorphologic, clinicopathologic, and immunophenotypic differences, HC-TCL likely represents a separate biological entity rather than a histomorphologic variant of HS-TCL.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 80%

Hepatosplenic and Hepatocytotropic T-Cell Lymphoma

et al. 2012

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“…A recent report using electron microscopy (EM) in 12 cats with T‐cell lymphoma revealed lymphocytes within invaginations of hepatocyte cell membranes termed ELI, as opposed to actual penetration through the membrane. In 4 of these cases, neoplastic lymphocytes contained eosinophilic cytoplasmic granules similar to large granular lymphocytes . Similar EM findings have been reported in canine hepatocytotropic lymphoma .…”

Section: Discussionsupporting

confidence: 76%

“…In 4 of these cases, neoplastic lymphocytes contained eosinophilic cytoplasmic granules similar to large granular lymphocytes. 1 Similar EM findings have been reported in canine hepatocytotropic lymphoma. 4 No electron microscopy was completed on the current case due to sample autolysis, and ELI could not be differentiated from emperipolesis in this cat.…”

Section: Discussionsupporting

confidence: 74%

“…The unique cytologic feature of this case was the appearance of neoplastic lymphocytes within hepatocyte cytoplasm, previously termed lymphocyte emperipolesis-like invasion (ELI) of hepatocytes. 1 Emperipolesis describes the process of cells entering, and possibly exiting, other cells, often without damage to the host or invading cell, also termed cell-in-cell interactions. 2 Histopathologic evidence of neoplastic lymphocyte emperipolesis in hepatocytes was first reported in 2 cats with hepatic and renal lymphoma.…”

Section: Discussionmentioning

confidence: 99%

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