1970
DOI: 10.1016/0021-8707(70)90060-2
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Emphysema with hereditary alpha-1 antitrypsin deficiency masquerading as asthma

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Cited by 26 publications
(12 citation statements)
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“…The most consistent difference is the much earlier age at which dyspnoea develops, usually in the third decade. The youngest recorded case is 22 years (Makino, Chosy, Valdivia, and Reed, 1970). In the present series the mean age at onset of dyspnoea was only 35 years; four-fifths of the patients in the deficient group were dyspnoeic before the age of 40 years and all before the age of 50 years.…”
Section: Resultscontrasting
confidence: 52%
“…The most consistent difference is the much earlier age at which dyspnoea develops, usually in the third decade. The youngest recorded case is 22 years (Makino, Chosy, Valdivia, and Reed, 1970). In the present series the mean age at onset of dyspnoea was only 35 years; four-fifths of the patients in the deficient group were dyspnoeic before the age of 40 years and all before the age of 50 years.…”
Section: Resultscontrasting
confidence: 52%
“…It has been reported that asthmatics with deficiency phenotypes have an earlier onset and are more likely to require steroid treatment [4,16,18], In the present study, the a|AT defi ciency was equally present in the atopic and nonatopic asthmatics. Similar to our study, Szczeklik et al [4] have found that defi ciency of aiAT occurred with equal fre quency in extrinsic and intrinsic asthma, whereas other studies [8,[19][20][21][22] found that the patients with a|AT deficiency suffered from extrinsic asthma.…”
Section: Discussionsupporting
confidence: 72%
“…It has been suggested that early signs of airflow obstruction in some with alpha 1-antitrypsin deficiency presents as clinical asthma (19,20). Identification of these "hidden" cases would allow early genetic counseling, identification of affected family members and provide therapeutic options such as augmentation therapy.…”
Section: Discussionmentioning
confidence: 99%