Emphysematous Cholecystitis Secondary to Fusobacterium nucleatum

Kunadia, Anuj; Leong, Michael; Komanduri, Karthikram; Abdelmasih, Randa; Tarasiuk-Rusek, Aneta

doi:10.7759/cureus.15660

Cited by 3 publications

(4 citation statements)

References 18 publications

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“…Prevotella was found to be the most abundant anaerobic organism isolated from patients undergoing liver resection who developed infected post-operative bilomas [28].Therefore, it is suggested that Prevotella may be an important role in biliary sepsis with implications for targeting it for treatment. Fusobacterium is an uncommon infectious organism, however, when present is associated with significant mortality rates [29,30]. It has been demonstrated to be an important causative organism of biliary sepsis (e.g.…”

Section: Discussionmentioning

confidence: 99%

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Metataxonomic analysis demonstrates a shift in duodenal microbiota in South African patients with obstructive jaundice: A pilot study

Hart,

Patel,

Maayer

et al. 2023

Preprint

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The human gastrointestinal tract (GIT) is home to an abundance of diverse microorganisms, and the balance of this microbiome plays a vital role in maintaining a healthy GIT. The obstruction of the flow of bile into the duodenum, resulting in obstructive jaundice (OJ), has a major impact on the health of the affected individual. This study sought to identify changes in the duodenal microbiota in South African patients with OJ compared to those without this disorder. Mucosal biopsies were taken from the duodenum of nineteen jaundiced patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and nineteen control participants (non-jaundiced patients) undergoing gastroscopy. DNA extracted from the samples was subjected to 16S rRNA amplicon sequencing using the Ion S5 TM sequencing platform. Diversity metrics and statistical correlation analyses with the clinical data were performed to compare duodenal microbial communities in both groups. Differences in the mean distribution of the microbial communities in the jaundiced and non-jaundiced samples were observed; however, this difference did not reach statistical significance. Of note, there was a statistically significant difference between the mean distributions of bacteria comparing jaundiced patients with cholangitis to those without. On further subset analysis, a significant difference was observed between patients with benign (Cholelithiasis) and malignant disease, namely head of pancreas (HOP) mass (p-values of 0.01). Beta diversity analyses further revealed a significant difference between patients with stone and non-stone related disease when factoring in the Campylobacter-Like Organisms (CLO) test status (p=0.048). This study demonstrated a shift in the microbiota in jaundiced patients, especially considering some underlying conditions of the upper GI tract. Future studies should aim to verify these findings in a larger cohort.

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Section: Discussionmentioning

confidence: 99%

“…Cholangitis requires an urgent procedure such as endoscopic retrograde pancreaticoduodenoscopy (ERCP) to allow drainage of the biliary system. This drainage allows the restoration of normal bile flow which allows the resolution of this disorder [29].…”

Section: Introductionmentioning

confidence: 99%

Metataxonomic analysis demonstrates a shift in duodenal microbiota in South African patients with obstructive jaundice: A pilot study

Hart,

Patel,

Maayer

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Therefore, it is suggested that Prevotella may be an important role in biliary sepsis with implications for targeting it for treatment. Fusobacterium is an uncommon infectious organism; however, when present, it is associated with significant mortality rates [ 30 , 31 ]. It has been demonstrated to be an important causative organism of biliary sepsis (e.g., in emphysematous cholecystitis) [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Metataxonomic Analysis Demonstrates a Shift in Duodenal Microbiota in Patients with Obstructive Jaundice

et al. 2023

View full text Add to dashboard Cite

The human gastrointestinal tract (GIT) is home to an abundance of diverse microorganisms, and the balance of this microbiome plays a vital role in maintaining a healthy GIT. The obstruction of the flow of bile into the duodenum, resulting in obstructive jaundice (OJ), has a major impact on the health of the affected individual. This study sought to identify changes in the duodenal microbiota in South African patients with OJ compared to those without this disorder. Mucosal biopsies were taken from the duodenum of nineteen jaundiced patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) and nineteen control participants (non-jaundiced patients) undergoing gastroscopy. DNA extracted from the samples was subjected to 16S rRNA amplicon sequencing using the Ion S5 TM sequencing platform. Diversity metrics and statistical correlation analyses with the clinical data were performed to compare duodenal microbial communities in both groups. Differences in the mean distribution of the microbial communities in the jaundiced and non-jaundiced samples were observed; however, this difference did not reach statistical significance. Of note, there was a statistically significant difference between the mean distributions of bacteria comparing jaundiced patients with cholangitis to those without (p = 0.0026). On further subset analysis, a significant difference was observed between patients with benign (Cholelithiasis) and malignant disease, namely, head of pancreas (HOP) mass (p = 0.01). Beta diversity analyses further revealed a significant difference between patients with stone and non-stone related disease when factoring in the Campylobacter-Like Organisms (CLO) test status (p = 0.048). This study demonstrated a shift in the microbiota in jaundiced patients, especially considering some underlying conditions of the upper GI tract. Future studies should aim to verify these findings in a larger cohort.

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“…The phenomenon was encountered during an autopsy and the condition was described as presence of gas in the lumen of gall bladder or biliary tree [3]. The reason behind the presence of air is bile infected with gas-producing bacteria (Clostridium species, Fusobacterium nucleatum, Escherichia coli, Klebsiella species, and anaerobic streptococci) [4,5]. According to the reports, the ischemia of the gall bladder is the main contributing factor for secondary infection occurrence with gas producing bacteria [6].…”

Section: Discussionmentioning

confidence: 99%

Emphysematous Calculous Cholecystitis Diagnosed with Abdominal CT in a Diabetic Female Patient – Case Report

Misimi,

Aliu,

Kanevce

et al. 2023

Prilozi

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Emphysematous cholecystitis is reported to have a low incidence of less than 1% in all cases of acute cholecystitis and yet a high mortality rate of up to 15%. It is most commonly seen in male diabetic patients with advanced age. The diagnosis is established with the presence of gas in the gallbladder lumen and/or within its wall which can be seen on plain abdominal radiography, abdominal ultrasound, and abdominal computerized tomography. The clinical presentation refers to one of acute cholecystitis, but the treatment requires prompt cholecystectomy since the patient’s condition can deteriorate due to the possibility of gallbladder perforation. We present a case of a 71-year-old female diabetic patient with calculous emphysematous cholecystitis treated with emergency open cholecystectomy.

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Emphysematous Cholecystitis Secondary to Fusobacterium nucleatum

Cited by 3 publications

References 18 publications

Metataxonomic analysis demonstrates a shift in duodenal microbiota in South African patients with obstructive jaundice: A pilot study

Metataxonomic analysis demonstrates a shift in duodenal microbiota in South African patients with obstructive jaundice: A pilot study

Metataxonomic Analysis Demonstrates a Shift in Duodenal Microbiota in Patients with Obstructive Jaundice

Emphysematous Calculous Cholecystitis Diagnosed with Abdominal CT in a Diabetic Female Patient – Case Report

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