Empirical and theoretical insights into the structural effects of selenite doping in hydroxyapatite and the ensuing inhibition of osteoclasts

Wu, Victoria; Ahmed, M.K.; Mostafa, Mervat S.; Uskoković, Vuk

doi:10.1016/j.msec.2020.111257

Cited by 37 publications

(8 citation statements)

References 98 publications

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“…In recent decades, metallic selenites have attracted great attention because of their different chemical structures and advanced physical properties such as pyroelectricity, ferroelectricity, and piezoelectricity, and their important role in human health, especially because selenium is an elemental component of several selenoproteins . Selenites can be considered as important lone-pair oxyanions, in which stereoactive nonbonded electron pairs are present and active free electron pair of the Se 4+ cations can induce second-order Jahn–Teller distortions and the formation of noncentrosymmetric or polar structures. − …”

Section: Introductionmentioning

confidence: 99%

Structure, Photoluminescence Emissions, and Photocatalytic Activity of Ag₂SeO₃: A Joint Experimental and Theoretical Investigation

et al. 2021

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In this paper, we report the synthesis of silver selenite (Ag2SeO3) by different methods [sonochemistry, ultrasonic probe, coprecipitation, and microwave-assisted hydrothermal methods]. These microcrystals presented a structural long-range order as confirmed by X-ray diffraction (XRD) and Rietveld refinements and a structural short-range order as confirmed by Fourier transform infrared (FTIR) and Raman spectroscopies. X-ray photoelectron spectroscopy (XPS) provided information about the surface of the samples indicating that they were pure. The microcrystals presented different morphologies and sizes due to the synthesis method as observed by field emission scanning electron microscopy (FE-SEM). The optical properties of these microcrystals were evaluated by ultraviolet–visible (UV–vis) spectroscopy and photoluminescence (PL) measurements. Thermal analysis confirmed the temperature stability of the as-synthetized samples. Further trapping experiments prove that the holes and hydroxyl radicals, to a minor extent, are responsible for the photocatalytic reactions. The experimental results are sustained by first-principles calculations, at the density functional theory (DFT) level, to decipher the structural parameters, electronic properties of the bulk, and surfaces of Ag2SeO3. By matching the experimental FE-SEM images and theoretical morphologies, we are capable of finding a correlation between the morphology and photocatalytic activity, along with photodegradation of the Rhodamine B dye under UV light, based on the different numbers of unsaturated superficial Ag and Se cations (local coordination, i.e., clusters) of each surface.

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Section: Introductionmentioning

confidence: 99%

Structure, Photoluminescence Emissions, and Photocatalytic Activity of Ag₂SeO₃: A Joint Experimental and Theoretical Investigation

et al. 2021

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“…7 Se-doped HAp has been studied for the inhibition of osteosarcoma and the promotion of bone tissue repair. [8][9][10] The use of selenium (Se), an essential trace element with anti-tumor properties, 11,12 can successfully avoid the side effects induced by conventional radiation medications, and has become the current research trend of osteosarcoma treatment. Se has been demonstrated to have a significant role in anti-tumor and bone-formation processes by affecting protein activity.…”

Section: Introductionmentioning

confidence: 99%

“…Kim et al 14 inhibited selenoproteins to regulate osteoclast differentiation. Despite relatively advanced methods for manufacturing [15][16][17] and biological evaluation [8][9][10]13,16 of Se-doped HAp, its in vivo distribution and metabolic patterns have not been thoroughly investigated to ensure a balance between the nanomaterials' antitumor activity and biosafety, leading to in vivo toxicity of the nanomaterials. 18 However, imaging tools may be able to effectively address the issue of nanomaterial in vivo distribution and metabolic patterns.…”

Section: Introductionmentioning

confidence: 99%

A report on Se/Eu-doped hydroxyapatite: crystal structure analysis, biological property assessment, and applications in osteosarcoma inhibition and bioimaging

et al. 2023

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“…Several types of non-stoichiometric HA have been prepared in laboratories for various purposes. For example, zirconia doped HA has shown lowered degree of crystallinity in accompany with hardness decrement (4) . Co-substitution of Zr 4+ and Ce 3+ ions in the molecular lattices of HA and Fluoro-HA has exhibited a positive consequence on their toughness (5) .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Alkaline-Treated Polycaprolactone and Zr-Hydroxyapatite as a Drug Delivery System in Dentistry

Thepsri¹,

Kaewsrichan²

2022

IJST

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Objectives: To develop alkaline-treated polycaprolactone (PCL) and Zrhydroxyapatite (Zr-HA) and fabricate their mixtures as drug delivery systems for dental application. Methods: PCL was subjected to hydrolysis by using concentrated NaOH. Zr-HA was synthesized by co-precipitation reaction that contained Ca(NO 3 ) 2 , (NH 4 ) 2 HPO 4 and ZrO 2 at 65 O C. The obtained materials were characterized by using techniques such as X-Ray Fluorescence, Fourier Transform Infrared Spectroscopy, X-Ray Diffraction, or rheometric analysis. Various compositions of the Zr-HA and the modified-PCL were used for preparing drug delivery systems, and properties including cytotoxicity, degradation, and toluidine blue (TB) binding/releasing were investigated. Findings: The synthesized Zr-HA was more non-stoichiometric than HAcontrol. Improved hydrophilicity was evident for the modified-PCL. Drug carriers composing of the Zr-HA and the modified-PCL were increasingly degradable in phosphate buffer saline solution compared to those containing HA/PCL-control, resulting in 9% and 6% weight loss after 8 weeks of the immersion, respectively. Binding of TB on the Zr-HA/the modified-PCL mixture increased while the release of such bound dye decreased in comparison with that of HA/PCL counterpart. All of the developed materials were non-cytotoxic based on MTT assay using L929 cell line. Novelty: Partial inclusion of Zr 4+ ions in Ca 2+ lattices of HA resulted in fairly degradable Zr-HA. Shortening the epsiloncaprolactone units of PCL by strong bases was simple in producing fragmented PCL polymer that exhibited improvement of hydrophilic interaction towards another. Varying the weight ratios of the Zr-HA and the modified-PCL when to prepare drug carriers is possible to acquire optimal binding/releasing profiles of drugs in dental cavities.

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Empirical and theoretical insights into the structural effects of selenite doping in hydroxyapatite and the ensuing inhibition of osteoclasts

Cited by 37 publications

References 98 publications

Structure, Photoluminescence Emissions, and Photocatalytic Activity of Ag₂SeO₃: A Joint Experimental and Theoretical Investigation

Structure, Photoluminescence Emissions, and Photocatalytic Activity of Ag₂SeO₃: A Joint Experimental and Theoretical Investigation

A report on Se/Eu-doped hydroxyapatite: crystal structure analysis, biological property assessment, and applications in osteosarcoma inhibition and bioimaging

Evaluation of Alkaline-Treated Polycaprolactone and Zr-Hydroxyapatite as a Drug Delivery System in Dentistry

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Empirical and theoretical insights into the structural effects of selenite doping in hydroxyapatite and the ensuing inhibition of osteoclasts

Cited by 37 publications

References 98 publications

Structure, Photoluminescence Emissions, and Photocatalytic Activity of Ag2SeO3: A Joint Experimental and Theoretical Investigation

Structure, Photoluminescence Emissions, and Photocatalytic Activity of Ag2SeO3: A Joint Experimental and Theoretical Investigation

A report on Se/Eu-doped hydroxyapatite: crystal structure analysis, biological property assessment, and applications in osteosarcoma inhibition and bioimaging

Evaluation of Alkaline-Treated Polycaprolactone and Zr-Hydroxyapatite as a Drug Delivery System in Dentistry

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Structure, Photoluminescence Emissions, and Photocatalytic Activity of Ag₂SeO₃: A Joint Experimental and Theoretical Investigation

Structure, Photoluminescence Emissions, and Photocatalytic Activity of Ag₂SeO₃: A Joint Experimental and Theoretical Investigation