Wire loop resistance is critical for microelectronic packaging because it directly in°uences the reliability of the product. Proposed herein is an e®ective method for predicting the resistance of a wire loop. A¯nite element (FE) model is developed for verifying the method. The wire geometry is modeled based on actual wire pro¯les captured with a high-speed camera. Based on this model, the e®ects of wire properties, residual stresses, loop shape and loop type on the wire loop resistance are studied. Simulations demonstrated that the shape of the loop could dramatically alter the wire loop resistance. On the other hand, the wire properties, residual stresses and loop type mildly a®ect the wire loop resistance. The standard loop is the more resistant loop than the N and M loops. By using a large and hard wire, moderately tensioning the wire loop and reducing the loop span, height and number of kinks, one can improve the wire loop resistance. This study should provide useful insights into loop design for modern microelectronic packaging.