In this paper, the author continues developing a philosophy of multiple simultaneous un/natural disasters (MSD) in terms of further development of epistemology of know-how, and the ontology of appearance/reality of such disasters, mostly in the light of globally relevant disasters during 2021, namely floods in central China and in Germany and Belgium, wildfires in Siberia, etc. The paper is a continuation of the research from the initial paper “Un/natural disasters, Philosophy of multiple simultaneous un/natural disasters” (Krkač, 2022) which concerns philosophy of MSDs during 2020, mostly in Croatia within the global context. The main issues in this text are epistemology and ontology of and in multiple simultaneous un/natural disasters, in terms of know-how and appearance-reality distinction. These are being analyzed in conceptual-morphological terms, the goal of which is reaching clear concepts of know-how and reality of and in MSDs which seem to have importance for our understanding of MSDs, deciding, and acting before, in, and after them. The critical finding is concerned with the fact that beyond global MSD hotspots, and beyond special services equipped and trained to act before, during and after MSDs, there is little understanding of and preparedness for MSDs, globally speaking and on average. This overall lack seems to be obvious, and the clearest proofs of it are MSDs in the period between 2020 and 2022.